P53蛋白质的末端二极结构预测及核心区点突变模拟研究

根据刘次全研究员等发现的蛋白质与其编码mＲＮＡ二级结构之间可能存在着二级结构单元 数目间的对应关系,首次深度参照Ｐ５３蛋白质Ｎ／Ｃ编码mＲＮＡ二级结构预测Ｐ５３蛋 白质Ｎ／Ｃ末端相应的二级结构。预测结果显示,在Ｐ５３蛋白质Ｎ端１－９３残基肽段可能存在四个α螺旋结构（１４－２６,３８－４６,５１－５６,６８－７０aa）。在Ｐ５３蛋白质Ｃ端单体聚合区以后的区域可能存在另外两个α螺旋（３６８－３７３,３８１－     

真核生物mRNA折叠结构与生物功能的理论研究

简要介绍和评述了预测ＲＮＡ折叠结构（主要是ＲＮＡ二级结构）的理论方法,对以ＲＮＡ二级结构为基础的ＲＮＡ三级结构的构建方法和分子力学进行了初步探索和研究。真核细胞前体ｍＲＮＡ中内含子的剪接过程涉及剪接位点（内含子的５′、３′剪接位点和分枝点）的核苷序列与一些小蛋白质分子之间特定的专一相互作用。对大量内含子、外显子－内含子－外显子以及外显子－外显子的核苷酸片段二级结构的分析表明,剪接位点大多位于二级结构的环区。剪接位点的这种结构分布特征与剪接过程的化学反应机制相符合,并可以作为识别剪接位点的一种结构信号。对ｍＲＮＡ和由其编码的蛋白质折叠结构进行比较研究后发现,两者之间存在着相关性：两者的二级结构单元（即ｍＲＮＡ二级结构的发夹,蛋白质中α－螺旋和β－折叠片）数基本上相同;蛋白质转角区域与ｍＲＮＡ二级结构的环区对应;两者的结构元素在空间上的排布相一致等。详细分析密码子在ｍＲＮＡ二级结构中的分布还发现,密码子在ＲＮＡ二级结构中的分布规律与氨基酸的构象性质有一定联系。这些结果提示,ｍＲＮＡ与蛋白质之间除了存在一维线性遗传关系外,很可能还存在着某种三维结构的遗传关系     

IRAS 02232+6138的13CO、C18O、HCO+和N2H+的观测研究

利用中国科学院紫金山天文台德令哈观测站13．7米望远镜在IRAS 02232 6138方向进行了13CO,C18O,HCO 和N2H 的观测．随着探针分子的激发密度从13CO到N2H 逐渐增加, IRAS02232 6138云核的尺度从13CO的2．40 pc减小到N2H 的0．54pc,云核的维里质量从13CO的2．2×103M⊙减小到N2H 的5．1×102M⊙．研究发现,该方向区域内存在双极分子外流．对云核的空间密度结构用幂函数n(r)αr-α的形式进行拟合分析,得到α=2．3-1．2;随着探测密度的增加,该指数逐渐变平．分析得到, 13CO／C18O分子丰度比值为12．4±6．9,与暗云的11．8±5．9及大质量核的9．0-15．6值一致;N2H 丰度是3．5±2．5×10-10,与暗云核的1．0-5．0×10-10和大质量核的1．2-12．8×10-10值一致;HCO 丰度为0．9±0．5×10-9,接近大质量核的1．6-2．4×10-9值,没有发现HCO 丰度增长．结合IRAS数据,得到云核的光度质量比范围为37-163(L／M)⊙,由IRAS光度估计, IRAS 02232 6138方向云核内嵌埋的大约是一颗主序O7．5星．     

光抽运铯原子束频标的二级多普勒频移研究

结合光抽运铯束频标的具体结构,论证了用余弦傅里叶逆变换的方法推导原子速度分布的可行性;用该理论对实验系统测量的Ramsey花样进行了分析,得到铯束管中有效原子真实的速度分布,该速度分布与铯束管的具体结构对速度的要求相一致;通过速度分布精确计算了影响光抽运铯束频标准确度的重要因素——二级多普勒频移,其大小为-3．5×10-13。     

面向类旋涡星系盘有效厚度的获取及图像处理方法

面向类(face-on)旋涡星系盘的有效厚度或标高不能通过表面亮度测光的方式测量.为了获得面向类旋涡星系盘的厚度参数,将基于三维星系盘引力势Poisson方程在等角对数螺旋型物质密度扰动情形下的解,运用一种解析法对面向类旋涡星系盘的标高进行测算.为了去除星系核球的光污染而获得旋臂最内点位置(r0)的重要参数,使用了在星系观测图像中扣除双成份(盘+核球)测光模型的图像处理方法.通过对旋涡星系相关结构参数的拟合测量,各得到了一个普通旋涡星系(S)与棒旋星系(SB)的有效厚度与相关参数,并给出了它们的球盘比(rb/rd)和星系盘的标长与厚度之比(rd/H).采用这种在观测图像中扣除双成份测光模型的方法,将更容易看清旋臂结构的最内端,因而这里获得的禁区半径r0的数值往往比从原星系图像上直接测量的数值要小,获得的星系盘有效厚度将更薄.     

彗星动态

沈髦票窦级是 只砰式孵的雏:吻冬卿叩‘/20叮倒SOHO)C刀002只6f只OHO、蟒吵黑器扮匆由C/2002补乃nn6娜6明S吕(s OHo)59伶oHO)s,o(s。叫T3(S0H伪只11了只OHO}卿吟“卿创篮梳彗早去n下,、C/加02C/199夕C/2002七/l 999C/2 002亡产之002 丫舒C/2002C/加02 汽C/2002C/2002Ul侈OHo)-M《SoH切U3(SOHO):伽玲叨o)U4(S OHO)us归OHo)_U邮oHQ)Uv(s0Ho)US侈OHO)Ug(s 0H0、卿娜2002﹄厂///P CC户C左002U2(LI NEAR\T6卿E八T共耳哪人耳‘T7(LlNE人R),-石(N‘劝一.一产-、一VZ(LI NE.Am一_-顿黔整罗鳄磊)糯霜是渠默糕君暑…     

红外暗云G79.2+0.38的性质

对MSX红外暗云G79.2+0.38的11'×7'的区域范围进行了12CO(1-0)、13CO(1-0)和C18O(1-0)谱线的同时观测.观测到的两个C18O(1-0)谱线所界定的云核峰值分布分别对应MSX A波段的两块高消光区域.该区域的氢分子柱密度N(H2)-(5-12)×1022 cm-2,平均密度n-(3±1)×104cm-3.两块分子云核的13CO的线尺度分别是1.7和1.2 pc,而C18O的线尺度分别是1.2和0.6 pc,它们包含的质量为2×102-2×103M(?).分子云核的视向平均密度结构可用幂函数(?)(p)-p-0.34±0.02表征. 13CO和C18O的丰度和典型的光学暗云相比低了4至11倍,但是目前还没有证据表明13CO和C18O的相对丰度比X13/18随柱密度有显著变化.     

DWT Power Spectrum of the Two-Degree Field Galaxy Redshift Survey

The power spectrum of the two-degree Field Galaxy Redshift Survey (2dFGRS) sample is estimated with the discrete wavelet transform (DWT) method. The DWT power spectra within 0.035 < k < 2.2 h Mpc-1 are measured for three volume-limited samples de-fined in consecutive absolute magnitude bins -19 ～-18, -20～ -19 and -21～-20. We show that the DWT power spectrum can effectively distinguish ACDM models of σs = 0.84 and σ8 = 0.74. We adopt maximum likelihood method to perform three-parameter fitting of the bias parameter b, pairwise velocity dispersion σpv and redshift distortion parame-ter β = Ω0.6m/b to the measured DWT power spectrum. The fitting results state that in a σ8= 0.84 universe the best-fit values of σm given by the three samples are mutually consis-tent within the range 0.28 ～ 0.36, and the best fitted values of σpv are 398 35-27475 37-29 and 550 ± 20km s-1 for the three samples, respectively. In the model of σ8 = 0.74, our three samples give very different values of Ωm. We repeated the fitting using the empirical formula of redshift distortion. The result of the model of low σ8 is still poor, especially, one of the best-fit values of σpv is as large as 103 km s-1. We also repeated our fitting by incorporating a scale-dependent galaxy bias. This gave a slightly lower value of Ωm. Differences between the models of σ8 = 0.84 and σ8 = 0.74 still exist in the fitting results. The power spectrum of 2dFGRS seems to disfavor models with low amplitude of density fluctuations if the bias parameter is assumed to be scale independent. For the fitting value of Ωm to be consistent with that given by WMAP3, strong scale dependence of the bias parameters is needed.     

窄线赛弗特Ⅰ星系Markarian478的远紫外成协吸收线(英文)

Markarian 478是典型的窄线赛弗特I星系之一。本文展示了在 2 0 0 1年 1月利用远紫外光谱探测卫星 (FUSE)观测到的Markarian 478的远紫外光谱。我们的光谱覆盖了 91 5Å ;— 1 1 85Å的波长范围 ,分辨率约为 2 0km/s。我们在连续谱上探测到OⅥλλ1 0 3 2 ,1 0 3 8、NⅢλ989和CⅢλ977强发射线。在高电离双线OⅥ以及Lyβ的蓝端线翼上出现了成协吸收线 ,而在NⅢ和CⅢ发射线上没有出现内禀吸收线。这些吸收线被分解成 5个动力学成分 ,它们相对于系统红移zem=0 .0 774的静止坐标系速度覆盖了从 -2 3 0 0～ 3 70km/s的范围     

武仙座TU——一颗周期在迅速减小的大陵五型双星

本文通过对食双星TU Her(周期:2.267天,光谱型:FO)的光变极小时刻的统计分析,进一步证实了周期在1910—1977年间,存在着迅速减小的现象,周期变化率ΔP/P～-1.29×10~(-3)=-0.41秒/年,并且得到了周期在长期稳定减小的同时,存在着三次可能的周期突变。作者定性讨论了周期变化的原因,认为可能是系统存在着物质损失的动力学演化效应所致。     

The 2/1 and 3/2 Resonant Asteroid Motion: A Symplectic Mapping Approach

A comparative study is made between the 2/1 and the 3/2 resonant asteroid motion, with the aim to understand their different behaviour (gap in the 2/1 resonance, group in the 3/2 resonance). A symplectic mapping model is used, for each of these two resonances, assuming the asteroid is moving in the three-dimensional space under the gravitational perturbation of Jupiter. It is found that these resonances differ in several points, and although there is, in general, more chaos in the phase space close to the 3/2 resonance, even in the model of circular orbit of Jupiter, there are regions, close to the secondary resonances, which are less chaotic in the 3/2 resonance compared to the 2/1 resonance, and consequently trapping can take place.     

The Effect of the Great Inequality on the Hecuba Gap

The effects of the "great inequality" (the quasi-resonance between Jupiter and Saturn) on the motion in the 2/1 mean motion resonance with Jupiter (the Hecuba gap) is investigated. We confirm the proposition made by Ferraz-Mello and collaborators that the great inequality generates secondary resonances which are likely to produce the slow diffusion observed in numerical investigations. We identify, in the restricted three body problem, the frequencies responsible for these secondary resonances. This revised version was published online in July 2006 with corrections to the Cover Date.     

低频地波场强和二次相位因子计算的可视化实现

准确计算地波场强和时延是利用BPL或罗兰-C定时的关键技术之一。利用VC++面向对象和可视化的程序设计实现了低频范围内任意距离上场强和二次相位因子的计算。MicrosoftWindows图形用户界面使得工程人员操作起来简单易懂,更加具有实用性。比较表明,该程序的计算结果与现有的数据吻合得非常好,计算结果准确度较高。     

A Symplectic Mapping Model as a Tool to Understand the Dynamics of 2/1 Resonant Asteroid Motion

We present a 3-D symplectic mapping model that is valid at the 2:1 mean motion resonance in the asteroid motion, in the Sun-Jupiter-asteroid model. This model is used to study the dynamics inside this resonance and several features of the system have been made clear. The introduction of the third dimension, through the inclination of the asteroid orbit, plays an important role in the evolution of the asteroid and the appearance of chaotic motion. Also, the existence of the secondary resonances is clearly shown and their role in the appearance of chaotic motion and the slow diffusion of the elements of the orbit is demonstrated. This revised version was published online in July 2006 with corrections to the Cover Date.     

Secondary uranium mineralization in southern Finland and its relationship to recent glacial events

Uranium series dating has been carried out on secondary uranyl silicate minerals formed during sub-glacial and post-glacial weathering of Proterozoic uraninite ores in south west Finland. The samples were obtained from two sites adjacent to the Salpauselkä III ice marginal formation and cover a range of depths, from the surface to more than 60 m. Measured ages fall into three distinct groups, 70–100 ka, 28–36 ka and < 2500 yr. The youngest set is associated with surface exposures and the crystals display clear evidence of re-working. The most likely trigger for uranium release at depths below the surface weathering zone is intrusion of oxidising glacial melt water. The latter is often characterised by very high discharge rates along channels, which close once the overpressure generated at the ice margin is released. There is excellent correspondence between the two Finnish sites and published data for similar deposits over a large area of southern and central Sweden. None of the seventy samples analysed gave a U–Th age between 40 and 70 ka; a second hiatus is apparent at 20 ka, coinciding with the Last Glacial Maximum. Thus, the process responsible for uranyl silicate formation was halted for significant periods, owing to a change in geochemical conditions or the hydrogeological regime. These data support the presence of interstadial conditions during the Early and Middle Weichselian since in the absence of major climatic perturbations the uranium phases at depth are stable. When viewed in conjunction with proxy data from mammoth remains it would appear that the region was ice-free prior to the Last Glacial Maximum.     

Surfaces of section in the Miranda-Umbriel 3:1 inclination problem

The recent numerical simulations of Tittemore and Wisdom (1988, 1989, 1990) and Dermottet al. (1988), Malhotra and Dermott (1990) concerning the tidal evolution through resonances of some pairs of Uranian satellites have revealed interesting dynamical phenomena related to the interactions between close-by resonances. These interactions produce chaotic layers and strong secondary resonances. The slow evolution of the satellite orbits in this dynamical landscape is responsible for temporary capture into resonance, enhancement of eccentricity or inclination and subsequent escape from resonance. The present contribution aims at developing analytical tools for predicting the location and size of chaotic layers and secondary resonances. The problem of the 3:1 inclination resonance between Miranda and Umbriel is analysed.     

太阳大气中环状结构的形状

根据力平衡条件,求得了与静止分层大气中一条孤立细磁通量管形状有关的一个积分,(1-M_a~2)Bcosθ=const.,这里M_a是阿尔芬马赫数,B是磁场强度,θ是管切向与水平方向的夹角,并简单地讨论了这个积分在等温与静平衡条件下的应用.     

Motion near the 3/1 resonance of the planar elliptic restricted three body problem

The global semi-numerical perturbation method proposed by Henrard and Lemaître (1986) for the 2/1 resonance of the planar elliptic restricted three body problem is applied to the 3/1 resonance and is compared with Wisdom's perturbative treatment (1985) of the same problem. It appears that the two methods are comparable in their ability to reproduce the results of numerical integration especially in what concerns the shape and area of chaotic domains. As the global semi-numerical perturbation method is easily adapted to more general types of perturbations, it is hoped that it can serve as the basis for the analysis of more refined models of asteroidal motion. We point out in our analysis that Wisdom's uncertainty zone mechanism for generating chaotic domains (also analysed by Escande 1985 under the name of slow Hamiltonian chaotic layer) is not the only one at work in this problem. The secondary resonance _p = 0 plays also its role which is qualitatively (if not quantitatively) important as it is closely associated with the random jumps between a high eccentricity mode and a low eccentricity mode.     

Wait公式与Millington经验公式预测地波时延的比较

为了了解用于预测沿光滑分段均匀混合路径传播的地波时延的Millington经验公式的实用性,对Millington经验公式和用于预测沿光滑分段均匀混合路径传播的地波时延的严格的Wait公式进行了比较。在Wait积分法用计算机软件实现的基础上,用上述2种方法分别计算多条实际路径的地波二次相位因子,并对计算结果进行了比较。比较结果表明,在实际工程应用中用Millington经验公式进行地波时延预测符合应用要求。     

关中平原大地等效电导率的间接测量

为准确预报地波传播时延,用电波传播法对关中平原的大地等效电导率进行了间接测量。阐述了电波传播法的测量原理和方法,第一次给出关中平原大地等效电导率的间接测量结果,同时,给出了中国科学院国家授时中心临潼科研楼参考点的BPL信号传播时延测量结果,并对这些测量结果进行了精度分析。