Proteomic aspects of infection by lymphocystis disease virus in Japanese flounder (Paralichthys olivaceus) |
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Authors: | Mingqing Xing Xiuqin Sun Fengrong Zheng Lingyun Qu Xuguang Hong Suqi Wu Minggang Zheng Jinxing Zhang |
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Institution: | (1) Laboratory of Genome Science, Tokyo University of Marine Science and Technology, Konan 4-5-7, Minato-ku, Tokyo 108-8477, Japan;(2) Faculty of Marine Science, Tokyo University of Marine Science and Technology, Konan 4-5-7, Minato-ku, Tokyo 108-8477, Japan; |
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Abstract: | To reveal the key factor in self-healing from LCDV (lymphocystis disease virus)-infected Japanese flounder (Paralichthys olivaceus), serum proteins from self-healing and sick Japanese flounder were separated by two-dimensional electrophoresis to screen
differentially expressed proteins. Protein spots demonstrating changes greater than two-fold in the expression level were
digested and further identified in capillary liquid chromatography tandem mass spectrometry (LC-MS/MS). Two immunity-relevant
proteins were thus identified as transferrin and the complement component C3 of Japanese flounder. These findings suggest
that the two proteins may play important roles in the self-healing of lymphocystis in Japanese flounder. This is an important
theoretical foundation to promote self-healing in LCDV-infected Japanese flounder by improving their innate immunity. |
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