脑膜瘤中砂粒体矿化研究

砂粒体矿化是脑膜瘤中常见的矿化类型,对其形成机理和矿物成分的分析可能会对肿瘤发生、发展的研究提供辅助信息。该研究选取人脑膜瘤中的砂粒体矿化作为研究对象,采用偏光显微镜、环境扫描电镜及能谱、X射线衍射仪、高分辨透射电镜和电子探针对样品的形貌、结构和成分进行测试分析,并以此为依据探讨脑膜瘤中砂粒体的形成机理。研究结果表明矿化的初期为沉淀在胶原纤维上的矿化小球,成分为磷酸八钙;矿化小球不断生长聚集,并逐步水解为碳羟磷灰石晶体,矿化的不断发展致使胶原纤维也发生矿化。砂粒体的同心层状构造是由螺旋状排列的矿化胶原纤维及沉淀在其上的矿化颗粒组成的集合体,而不是多数研究中所述:砂粒体是以坏死细胞残骸为中心由内至外的同心层沉淀。

A study of the psammoma body mineralization in meningioma

The psammoma body mineralization in meningioma is a common type of mineralization.The analysis of the mineral composition may provide some support information in finding the reason of happening and developing of the disease.This paper focuses on the concentric layered structure mineralization in meningiomas,using mineralogical methods,such as HRSEM,ESEM,EDAX,EPMA,HRTEM,XRD and FTIR to systematically investigate the mineral composition,structure and shape of the minerals in psammoma bodies in meningiomas.We have devised a method for preparing the silicon wafer sheet which was used for the ESEM in-situ observations and analysis.In this study,we first got the ESEM and HRTEM images of the initial mineralization phase of meningiomas.These images showed that in the early stage of psammoma body mineralization in meningiomas,many mineralized balls composed of octocaphosphate were precipitated on the collagen fibers.These balls continued to grow and aggregate,and were gradually hydrolyzed to become the dahllite.The continued development of mineralization resulted in the mineralized collagen fibers.The study revealed that the concentric layered structure of the psammoma bodies in meningiomas is formed by the spiral arrangement of the mineralized collagen fibers on which the mineralized grains precipitated.