| Sinularia tenellaLi中的西松烯二萜内酯的抗肿瘤活性 |
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| 引用本文： | 戚穗坚,陈琪,彭文烈,徐安龙.Sinularia tenellaLi中的西松烯二萜内酯的抗肿瘤活性[J].热带海洋学报,2002,21(1):87-91. |
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| 作者姓名： | 戚穗坚 陈琪 彭文烈 徐安龙 |
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| 作者单位： | 中山大学生命科学学院生物化学系,广东,广州,510275 |
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| 基金项目： | NationalNewDrugFundforDoctorsofMinistryofScienceandTechnology ( 4 1 70 35 ) |
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| 摘 要： | 首次报道了柔弱短指软珊瑚Sinularia tenella Li中的3个主要的西松烯二萜内酯；dihydroflexibilide(1),flexibilide(2)sinulariolide（3）的分离和体外抗肿瘤活性。这3个化合物都显示出较强的抗肿瘤活性。
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| 关 键 词： | 软珊瑚 Sinularia tenella Li 西松烯二萜内酯 细胞毒性 |
CYTOTOXIC PROPERTIES OF CEMBRENOLIDE DITERPENOIDS FROM SOFT CORAL SINULARIA TENELLA LI |
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| QI Sui-Jian,CHEN Qi,PENG Wen-lie,XU An-long.CYTOTOXIC PROPERTIES OF CEMBRENOLIDE DITERPENOIDS FROM SOFT CORAL SINULARIA TENELLA LI[J].Journal of Tropical Oceanography,2002,21(1):87-91. |
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| Authors: | QI Sui-Jian CHEN Qi PENG Wen-lie XU An-long |
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| Abstract: | Dihydroflexibilide (1), flexibilide (2), sinulariolide (3), these three cembrenolide diterpenoids were isolated from marine soft coral Sinularia tenellaLi for the first time. Their in vitro cytotoxicities on five human carcinoma cell lines were studied and reported for the first time. These three compounds all exhibited strong antitumor activities. |
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| Keywords: | soft coral Sinularia tenellaLi cembrenolide diterpenoid cytotoxicity |
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