| 几丁糖酯原料药稳定性研究 |
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| 引用本文： | 吕志华,赵峡,徐家敏.几丁糖酯原料药稳定性研究[J].中国海洋大学学报(自然科学版),2001,31(6):842-848. |
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| 作者姓名： | 吕志华 赵峡 徐家敏 |
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| 作者单位： | 青岛海洋大学海洋药物与食品研究所, |
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| 基金项目： | 国家 8 6 3项目 ( 81 9-0 7-0 3)资助 |
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| 摘 要： | 该文建立高效凝胶渗透色谱法 (HPGPC) ,明胶比浊法 ,氧瓶燃烧法三种分析方法考察海洋硫酸多糖药物几丁糖酯的稳定性 ,采用这三种方法分别考察几丁糖酯原料药在高温、高湿、强光照射及加速条件下分子量及分布宽度、样品中硫酸根含量及样品含量的变化情况。结果表明 :三种方法均适用于几丁糖酯的稳定性考察 ,几丁糖酯在上述影响因素条件下稳定性良好
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| 关 键 词： | 几丁糖酯 稳定性 高效凝胶渗透色谱法 明胶比浊法 氧瓶燃烧法 |
| 文章编号： | 1001-1862(2001)06-842-07 |
| 修稿时间： | 2000年12月29 |
Study on the Stability of Chitosan Ester |
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| Lv Zhihua\ Zhao Xia\ Xu Jiamin.Study on the Stability of Chitosan Ester[J].Periodical of Ocean University of China,2001,31(6):842-848. |
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| Authors: | Lv Zhihua\ Zhao Xia\ Xu Jiamin |
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| Abstract: | Three methods including high performance gel permeation chromatography, gelatin nephelometry and oxygen flask were established for testing the stability of marine polysaccharide drug chitosan ester. Samples were tested in high temperture,high humidity,strong light and accelerated test conditions.Molecular weight and molecular weight distribution, sulfate content and chitosan ester content were determined respectivily by these three methods. The results showed: The three methods were suitibable to test the stability of chitosan ester, the stability of chitosan ester was good in these conditions as before. |
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| Keywords: | Chitosan ester stability oxygen flask method high performance gel permeation chromatography Gelatin nephelometry |
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