A multi-biomarker approach to assess effects of Triclosan in the clam Ruditapes philippinarum |
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| Institution: | 1. Instituto de Ciências Biológicas, Programa de Pós-graduação em Fisiologia Animal Comparada, Universidade Federal do Rio Grande, Av Itália, km8, s/n, Rio Grande, Rio Grande do Sul State 96203-900, Brazil;2. Laboratório de Análises de Compostos Orgânicos e Metais, Escola de Química e Alimentos, Programa de Pós-graduação em Química Tecnológica e Ambiental, Universidade Federal do Rio Grande, Av Itália, km8, s/n, Rio Grande, Rio Grande do Sul State 96203-900, Brazil;1. Cawthron Institute, Nelson, New Zealand;2. School of Biological Sciences, University of Auckland, Auckland, New Zealand |
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| Abstract: | The effects of 7 days’ exposure to differing Triclosan (TCS) concentrations (300, 600, and 900 ng/L) were investigated in the clam Ruditapes philippinarum. Vitellogenin (Vg)-like protein levels in haemolymph and digestive gland from males and females, gill acetylcholinesterase (AChE) activity, superoxide dismutase (SOD) and catalase (CAT) activities in gills and digestive gland, and gill lipid peroxidation (LPO) were measured. The highest TCS concentrations decreased significantly Vg levels in male haemolymph and digestive gland, whereas no significant variations were found in females. The highest TCS concentrations increased significantly SOD activity in gills, but decreased it in digestive gland. No changes in CAT activity were observed. In gills, TCS reduced significantly AChE activity, but it did not induce significant variations in LPO. Our study demonstrates that TCS alters biochemical parameters in R. philippinarum, even at environmentally realistic concentrations, and suggests differing modes of action of the contaminant, in clams at least. |
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