Effects of several salt marsh plants on mouse spleen and thymus cell proliferation using mtt assay |
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| Authors: | Youngwan Seo Hee-Jung Lee You Ah Kim Hyun Joo Youn Burm-Jong Lee |
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| Institution: | (1) Division of Marine Environment and Biosciences, Korea Maritime University, 606-791 Busan, Korea;(2) Research Institute of Marine Science and Technology(RIMST), Korea Maritime University, 606-791 Busan, Korea;(3) Department of Microbiology and School of Biotechnology & Biomedical Science, Inje University, 621-749 Gimhae, Korea;(4) Department of Chemistry, Inje University, 621-749 Gimhae, Korea |
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| Abstract: | In the present study, we have tested the effects of 21 salt marsh plants on cell proliferation of mouse immune cells (spleen
and thymus) using MTT assay in culture. The methanolic extracts of six salt marsh plants (Rosa rugosa, Ixeris tamagawaensis, Artemisia capillaris, Tetragonia tetragonoides, Erigeron annus, and Glehnia littoralis) showed very powerful suppressive effects of mouse immune cell death and significant activities of cell proliferationin vitro. Especially, the methanolic extract ofRosa rugosa was found to have fifteen times compared to the control treatment, demonstrating that Rosa rugosa may have a potent stimulation
effect on immune cell proliferation. These results suggest that several salt marsh plants includingRosa rugosa could be useful for further study as an immunomodulating agent. |
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| Keywords: | salt marsh spleen thymus MTT |
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