能谱CT定量分析对肺鳞癌与腺癌的鉴别诊断价值

目的:探讨能谱CT多参数定量分析在肺鳞癌与腺癌中的鉴别价值.方法:搜集我院经病理证实并行能谱CT扫描的肺癌患者75例,其中鳞癌40例、腺癌35例.测量并比较两组病例的动脉期及静脉期的能谱参数.结果:动脉期及静脉期腺癌的能谱曲线(λ40～65keV)、有效原子序数、碘(水)浓度、标准化碘浓度均大于鳞癌,差异有统计学意义,...

The Value of Spectral CT Quantitative Analysis in the Differential Diagnosis of Lung Squamous Cell Carcinoma and Adenocarcinoma

Objective: To investigate the value of energy spectrum CT multi-parameter quantitative analysis in the differential diagnosis of lung squamous cell carcinoma and adenocarcinoma. Methods: Seventy-five patients with lung cancer who were confirmed by pathology and underwent energy spectrum CT scanning were collected, including 40 cases of squamous cell carcinoma and 35 cases of adenocarcinoma. We measured and compared the energy spectrum parameters of arterial phase and venous phase between the two groups. Results: The spectrum curve of adenocarcinoma (λ_{40～65 keV}) in arterial and venous phase, effective atomic number, concentration of iodine (water) and standardized iodine concentration were greater than that of squamous carcinoma, the difference was statistically significant, the difference of water (iodine) concentration between the two groups of arterial phase held no statistical significance, the water (iodine) concentration of adenocarcinoma was lower than that of squamous cell carcinomas, the difference was statistically significant. The results of ROC curve analysis showed that the energy spectrum (λ_{40～65 keV}) in the venous phase was of great value in the differentiation of squamous cell carcinoma and adenocarcinoma, with the AUC of 0.839, the sensitivity of 88.6% and the specificity of 72.5%. Conclusion: Adenocarcinoma and squamous cell carcinoma of lung show different energy spectrum CT parameters. It holds certain value to distinguish them, which can provide a new method for preoperative diagnosis.