Developmental,Reproductive, and Demographic Alterations in Aquatic Wildlife: Establishing Causality between Exposure to Endocrine‐active Compounds (EACs) and Effects

This brief overview discusses the difficulty of demonstrating causal associations between exposure to endocrine active compounds (EACs) and the occurrence of developmental, reproductive, or demographic disturbances in aquatic wildlife. While for biological responses at the suborganism level correlational or causal evidence of an EAC etiology has been established in a number of cases, well proven examples of ecological consequences of endocrine disruption are rather few in number. The attribution of causality is complicated due to (i) lack of data on EAC exposure and bioaccumulation, (ii) lack of specific biomarkers and endpoints, together with insufficient knowledge on the mechanisms and conditions by which EAC‐induced disruption of endocrine functions translates into impaired organism development and reproduction, and (iii) insufficient understanding of the importance of species diversity in endocrine physiology and life histories for the consequences of endocrine disruption. Future research should address these gaps in our understanding of EAC exposure and effects, but additionally needs to pay more attention (i) to ecological determinants influencing the population‐level consequences of the endocrine disruption of developÍmental and reproductive functions, and (ii) to the use of epidemiological principles and approaches.