螺旋CT灌注成像在肾上腺增生的诊断价值

目的：研究多层螺旋CT灌注成像在肾上腺增生的诊断价值。方法：对23例正常肾上腺和18例经临床证实的肾上腺增生进行16层螺旋CT灌注成像研究,利用CT灌注软件计算灌注参数,包括相对血流量（RBF）、平均通过时间（MTT）和表面通透性（PS）,参数间比较采用t检验。结果：正常肾上腺的RBF、MTT和PS分别为0.63±0.22mL/100g/min、70.65±12.31s和0.72±0.13mL/100g/min,肾上腺增生RBF、MTT和PS分别为0.45±0.19mL/100g/min、118.39±19.98s和0.49±0.21mL/100g/min。正常肾上腺的RBF、PS均大于肾上腺增生,肾上腺增生的MTT大于正常肾上腺,其差异有统计学意义（t值分别为15.91、20.03和9.96,P〈0.05）。结论：肾上腺多层螺旋CT灌注成像是可行的肾上腺功能成像检查,它反映了肾上腺微循环的血流灌注状况,为肾上腺增生的诊断提供有用的信息。

The Value of Spiral CT Perfusion Imaging in Diagnosis of Adrenal Hyperplasia

Objective:To study the clinical application value of spiral CT perfusion imaging in diagnosis of adrenal hyperplasia.Methods:Spiral CT perfusion imaging was performed in 23 healthy volunteers and 18 patients with adrenal hyperplasia.CT perfusion parameters including relative blood flow(RBF),mean transmit time(MTT)and permeability surface(PS)were analyzed.The test was used in the statistical analysis for the CT perfusion parameters.Results:RBF,MTT and PS of normal adrenal gland were 0.63±0.22 mL/100g/min,70.65±12.31 s,0.72±0.13 mL/100g/min respectively.RBF,MTT and PS of adrenal hyperplasia were 0.45±0.19 mL/100g/min,118.39±19.98 s,0.49±0.21 mL/100g/min respectively.RBV and PS in normal adrenal gland were higher than that of adrenal hyperplasia,while MTT in adrenal hyperplasia was higher than that of normal adrenal gland.There was significant difference of RBF,MTT and PS between normal adrenal gland and adrenal hyperplasia(t=15.91,20.03,9.96,respectively,P<0.05).Conclusion:Spiral CT perfusion imaging is a feasible functional examination for adrenal gland.It reflects the microcirculatory blood flow of adrenal gland and provides useful information for differential diagnosis in adrenal hyperplasia.