| 深海热液真菌Fusarium sp. SCSIO 06196中抗病毒聚酮类化学成分研究 |
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| 引用本文： | 王俊锋,周雯颖,田新朋,刘永宏.深海热液真菌Fusarium sp. SCSIO 06196中抗病毒聚酮类化学成分研究[J].热带海洋学报,2022,41(5):189-193. |
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| 作者姓名： | 王俊锋 周雯颖 田新朋 刘永宏 |
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| 作者单位： | 1.中国科学院南海海洋研究所, 热带海洋生物资源与生态重点实验室, 广东 广州 5103012.广州中医药大学, 第五临床医学院, 广东 广州 510405 |
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| 摘 要： | 从西太平洋深海热液沉积物来源的镰刀菌SCSIO 06196中分离鉴定了6个色原酮类化合物(1~6), 通过核磁共振光谱、质谱及旋光等多种分析测试方法确定了色原酮类化合物的结构。抗病毒活性筛选发现, 化合物1~3展示出显著的抗肠道病毒EV-71活性, IC50分别达到26.7μmol?L-1、19.8μmol?L-1和22.0μmol?L-1 (阳性对照药物利巴韦林为177μmol?L-1)。此外, 化合物1还显示出弱的抗流感病毒H3N2活性, IC50为8.6μmol?L-1 (阳性对照药物达菲为18.5nmol?L-1)。
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| 关 键 词： | 深海热液 聚酮 抗肠道病毒活性 抗流感病毒活性 |
| 收稿时间： | 2021-12-30 |
| 修稿时间： | 2022-03-01 |
Antiviral chromones from the deep-sea hydrothermal-vent-derived Fusarium sp. SCSIO 06196 |
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| WANG Junfeng,ZHOU Wenying,TIAN Xinpeng,LIU Yonghong.Antiviral chromones from the deep-sea hydrothermal-vent-derived Fusarium sp. SCSIO 06196[J].Journal of Tropical Oceanography,2022,41(5):189-193. |
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| Authors: | WANG Junfeng ZHOU Wenying TIAN Xinpeng LIU Yonghong |
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| Institution: | 1. CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China2. Fifth School of Clinical Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510405, China |
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| Abstract: | Six chromone derivatives (1 ~ 6) were identified from the fungus Fusarium sp. SCSIO 06196 isolated from deep-sea hydrothermal vent environments in the Western Pacific. Their structures were elucidated mainly by extensive Nuclear Magnetic Resonance (NMR) spectroscopic, mass spectrometric (MS) and rotational analysis. Antiviral activities of the compounds 1 ~ 6 were tested. Among these compounds, compounds 1 ~ 3 exhibited significant in vitro anti-enterovirus 71 (EV-71) activities with IC50 values of 26.7, 19.8, and 22.0 μmol?L-1, respectively (IC50=177 μmol?L-1, Ribavirin). In addition, compound 1 showed weak antiviral activity against the H3N2 influenza virus with IC50 value of 8.6 μmol?L-1 (IC50=18.5 nmol?L-1, Tamiflu). |
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| Keywords: | deep-sea hydrothermal vent polyketide anti-EV 71 activity anti-H3N2 activity |
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