| 相转移催化法制备抗癌新药工艺 |
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| 引用本文： | 于静,李英霞,孙红艳.相转移催化法制备抗癌新药工艺[J].中国海洋大学学报(自然科学版),1992(Z1). |
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| 作者姓名： | 于静 李英霞 孙红艳 |
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| 作者单位： | 青岛海洋大学海洋药物与食品研究所，青岛海洋大学海洋药物与食品研究所，青岛海洋大学海洋药物与食品研究所 1991届毕业研究生 |
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| 摘 要： | 提出采用相转移催化法,一步合成了抗癌新药ASF。工艺条件达到最简。利用正交实验法确定了最佳反应条件,通过一系列分析手段确定产物结构。
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| 关 键 词： | 相转移催化法 抗肿瘤新药(ASF) 5-氟尿嘧啶 褐藻酸 |
MANUFACTURE OF A NEW ANTITUMOR AGENT WITH PHASE TRANSFER CATALYST |
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| Yu Jing Li Yingxia Sun Hongyan.MANUFACTURE OF A NEW ANTITUMOR AGENT WITH PHASE TRANSFER CATALYST[J].Periodical of Ocean University of China,1992(Z1). |
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| Authors: | Yu Jing Li Yingxia Sun Hongyan |
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| Institution: | Institute of Marina Drugs and Foods |
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| Abstract: | A new antitumor agent was made by one-step synthesis with phase transfer catalyst.The influence of four facctors on the reaction is discussed.An orthogonol plan was established and the optimum plan was found out.The structure was characterized by 13C-NMR,IR as well as UV spectra. |
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| Keywords: | phase transfer catalytic method antitumor new drug (ASF) algi-nate 5-fluorouracilum |
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