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| 钝顶螺旋藻藻蓝蛋白和多糖的抗肿瘤免疫活性研究 | |
| 引用本文： | 李冰,张学成,高美华,于红.钝顶螺旋藻藻蓝蛋白和多糖的抗肿瘤免疫活性研究[J].中国海洋大学学报(自然科学版),2004,34(3):396-402. |
| 作者姓名： | 李冰 张学成 高美华 于红 |
| 作者单位： | 1. 中国海洋大学海洋生命学院,山东,青岛,266003 2. 青岛大学医学院,山东,青岛,266003 3. 中国海洋大学海洋生命学院,山东,青岛,266003;青岛大学医学院,山东,青岛,266003 |
| 基金项目： | 国家九五攻关项目 ( 96-c0 2 -0 4-0 5 )资助 |
| 摘 要： | 对钝顶螺旋藻藻蓝蛋白 (PC)和多糖 (PSP)的抗肿瘤免疫活性进行了研究。采用免疫酶标技术、MTT法及定量溶血分光光度测定法等免疫分析实验 ,从免疫器官、免疫细胞、免疫分子 3个水平上进行藻蓝蛋白和多糖的抗肿瘤免疫活性检测。结果显示 ,藻蓝蛋白和多糖处理组小鼠瘤块直径及瘤体重量均小于对照组 ,T细胞及 B细胞活性明显增强 ,体液抗体量显著提高 ,螺旋藻藻蓝蛋白比多糖抑制肿瘤细胞生长和提高机体免疫力的作用更明显。 |
| 关 键 词： | 螺旋藻 藻蓝蛋白 多糖 免疫活性 抗肿瘤 |
| 文章编号： | 1672-1574(2004)03-396-07 |
| 修稿时间： | 2003年7月3日 |
Study on the Antitumor Immune Activities of Phycocyanin and Polysaccharide from Spirulina platensis |
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| LI Bing ,ZHANG Xue-cheng ,GAO Mei-hua ,YU Hong.Study on the Antitumor Immune Activities of Phycocyanin and Polysaccharide from Spirulina platensis[J].Periodical of Ocean University of China,2004,34(3):396-402. | |
| Authors: | LI Bing ZHANG Xue-cheng GAO Mei-hua YU Hong |
| Institution: | LI Bing 1,ZHANG Xue-cheng 1,GAO Mei-hua 2,YU Hong 1,2 |
| Abstract: | In this paper, we report the verification of the antitumor immune effects of the phycocyanin and polysaccarides isolated from blue-green alga Spirulina platensis by the ELISA,MTT and QHS methods at immune organic, cellular and molecular levels. The results show that the phycocyanin and polysaccarides have noticeable effects on antitumor immune activities. Compared with the control group, the size and weight of the tumor in groups treated with phycocyanin and polysaccharides are significantly smaller, the activity of T and B lymphocytes are markedly strengthened, and the quantity of the antibody is greatly enhanced as well. And it is found that the phycocyanin is better than the polysaccharides in tumor inhibition and immunity enhancement. |
| Keywords: | Spirulina phycocyanin polysaccharides immune activity antitumor |
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