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Immune functional impacts of oyster peptide-based enteral nutrition formula (OPENF) on mice: a pilot study |
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| Authors: | CAI Bingna PAN Jianyu WU Yuantao WAN Peng SUN Huili |
| Affiliation: | 1. Key Laboratory of Marine Bio-Resources Sustainable Utilization, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China;University of Chinese Academy of Sciences, Beijing 100049, China 2. Key Laboratory of Marine Bio-Resources Sustainable Utilization, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China 3. Bureau of Science and Technology for Resource and Environment, Chinese Academy of Sciences, Beijing 100864, China |
| Abstract: | Oyster peptides were produced from Crassostrea hongkongensis and used as a new protein source for the preparation of an oyster peptide-based enteral nutrition formula (OPENF). Reserpineinduced malabsorption mice and cyclophosphamide-induced immunosuppression mice were used in this study. OPENF powder is light yellow green and has a protein-fat-carbohydrate ratio of 16:9:75 with good solubility in water. A pilot study investigating immune functional impacts of the OPENF on mice show that the OPENF enhanced spleen lymphocyte proliferation and the activity of natural killer (NK) cells in BALB/c mice. Furthermore, OPENF can improve intestinal absorption, increase food utilization ratio, and maintain the normal physiological function of mice. These results suggest that oyster peptides could serve as a new protein source for use in enteral nutrition formula, but more importantly, also indicate that OPENF has an immunostimulating effect in mice. |
| Keywords: | marine protein oyster peptides enteral nutrition formula immunomodulation |
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