| The Antitumor Components from Marine-derived Bacterium Streptoverticillium luteoverticillatum 11014 Ⅱ |
| |
| 作者姓名： | LI Dehai ZHU Tianjiao FANG Yuchun LIU Hongbing GU Qianqun ZHU Weiming |
| |
| 作者单位： | Key Laboratory of Marine Drug Chinese Ministry of Education, Institute of A larine Drug and Food,Ocean University of China, Qingdao 266003, P. R. China |
| |
| 基金项目： | The work was financially supported by the Project of Chinese National Programs for High Technology Research and Development （No. 2003AA624020）, and the National Nattual Science Foundation of China （Nos. 30472136 and 30470196）. |
| |
| 摘 要： | Eight known compounds were isolated from a marine-derived bacterium Streptoverticillium luteoverticillatum 11014 using bioassay-guided fractionations. Their structures were identified by spectral analysis as bis （4-hydroxybenzyl） ether （1）, p-hydroxyphenylethyl alcohol （2）, N-（4-hydroxyphenethyl） acetamide （3）, indole-3 carboxylic acid methyl ester （4）, dibenzob,e] 1,4]dioxine （5）, thymine （6）, cytosine deoxyribonucleoside （7） and 2, 3-butanediol （8）. These compounds were evaluated for their cytotoxic activities against K562 cell line with the SRB method for the first time. Compounds 2 and 4 showed cytotoxcities with IC50 values of 101.1 and 165.3 μolL^-1, respectively. All compounds were isolated from S. luteoverticillatum 11014 for the first time.
|
| 关 键 词： | 海洋细菌 海洋放线菌 抗肿瘤成分 分离 |
| 收稿时间： | 2006-06-23 |
| 修稿时间： | 2007-01-05 |
The antitumor components from marine-derived bacterium <Emphasis Type="Italic">Streptoverticillium luteoverticillatum</Emphasis> 11014 II |
| |
| LI Dehai ZHU Tianjiao FANG Yuchun LIU Hongbing GU Qianqun ZHU Weiming.The antitumor components from marine-derived bacterium Streptoverticillium luteoverticillatum 11014 II[J].Journal of Ocean University of China,2007,6(2):193-195. |
| |
| Authors: | Li Dehai Zhu Tianjiao Fang Yuchun Liu Hongbing Gu Qianqun Zhu Weiming |
| |
| Institution: | (1) Key Laboratory of Marine Drug Chinese Ministry of Education, Institute of Marine Drug and Food, Ocean University of China, Qingdao, 266003, P. R. China |
| |
| Abstract: | Eight known compounds were isolated from a marine-derived bacterium Streptoverticillium luteoverticillatum 11014 using bioassay-guided fractionations. Their structures were identified by spectral analysis as bis (4-hydroxybenzyl)
ether (1), p-hydroxyphenylethyl alcohol (2), N-(4-hydroxyphenethyl) acetamide (3), indole-3 carboxylic acid methyl ester (4), dibenzolb,e] 1,4]dioxine (5), thymine (6), cytosine deoxyribonucleoside (7) and 2, 3-butanediol (8). These compounds were evaluated for their cytotoxic activities against K562 cell line with the SRB method for the first
time. Compounds 2 and 4 showed cytotoxicities with IC50 values of 101.1 and 165.3 μmolL−1, respectively. All compounds were isolated from S. luteoverticillatum 11014 for the first time. |
| |
| Keywords: | marine-derived bacterium Streptoverticillium luteoverticillatum antitumor activity |
| 本文献已被 CNKI 维普 SpringerLink 等数据库收录！ |
