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STUDIES ON THE ANTITUMOR ACTIVITY AND ISOLATION OF THE GLYCOPROTEIN FROM THE GONAD OF CHLAMYS (AZUMAPECTEN) FARRERI
Authors:GU Qian-qun  FANG Yu-chun  WANG Chang-yun  XIAO Hans  QIN Th-qing
Abstract:After being degreased with acetone, the feInal gonad of Chlamys (Azumapecten)farreri was extracted with watr, and then subjected to DEAE - cellulose column chromatogrphyy and pu-rified by Sephadex G - 100 chromatography to obain a pure female gonad glycoprotein (FGGP). The IRspectra, electrophoresis and chemical analysis of FGGP indicated tha it was a kind of acid glycoproteinand that the content of total protein and sugar were 54. 8% and 40%, respectively. Pharmacological testsshawd that FGGP could inhibit (inhibition rate of 40. 87% ) the growth of Sarorna 180 of mice.
Keywords:Chlamys (Azumapecten) farreri  gonad  glycoprotein  antitumor activity
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