Histopathology alterations and histochemistry measurements in mussel,Mytilus edulis collected offshore from an aluminium smelter industry (Norway) |
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| Institution: | 1. College of Fisheries and Life Science, Shanghai Ocean University, Shanghai, 201306, China;2. Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources, Shanghai Ocean University, Ministry of Education, China;3. Department of Integrative Ecophysiology, Alfred-Wegener-Institute Helmholtz Center for Polar- and Marine Research, 27570 Bremerhaven, Germany;4. Department of Zoology, Govt. College Women University Faisalabad, Pakistan;1. Instituto de Diversidad y Ecología Animal (CONICET-UNC), Facultad de Ciencias Exactas Físicas y Naturales, Universidad Nacional de Córdoba, Av. Vélez Sársfield 299, X5000JJC Córdoba, Argentina;2. Cátedra de Diversidad Animal II, Facultad de Ciencias Exactas Físicas y Naturales, Universidad Nacional de Córdoba, Av. Vélez Sársfield 299, X5000JJC Córdoba, Argentina;3. Centro de Investigaciones en Bioquímica Clínica e Inmunología—CIBICI, Facultad de Ciencias Químicas, CONICET, UNC, Haya de la Torre esq., Medina Allende, 5000 Córdoba, Argentina;1. Department of Marine Ecosystem Functioning, University of Gdańsk, Al. Pi?sudskiego 46, 81-378 Gdynia, Poland;2. Department of Pharmaceutical Biochemistry, Medical University of Gdańsk, ul. D?binki 1, 80-211 Gdańsk, Poland;3. Department of Marine Biotechnology, University of Gdańsk, Al. Pi?sudskiego 46, 81-378 Gdynia, Poland |
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| Abstract: | Histopathological characteristics of specific organs express condition, and represent time-integrated impacts on the organism stemming from alterations at lower levels of biological organisation. As integrative parameters, histochemical investigations have proved to be sensitive tools to detect effects of chemical compounds.The objective of this study was to determine changes in the tissues of mussels collected at a PAH contaminated site compared to a reference site using histopathological and histochemical parameters: lipofuscin (LF) accumulation in mussel digestive gland, and lysosomal membrane stability (LMS), and using additional information provided by body burden analysis to compare the sensitivity of these parameters.The histochemical measurements for both LF and LMS gave a clear indication of a high level of stress in animals from the PAH contaminated site. This LF accumulation in lysosomes is the result of peroxidation of autophagocytosed proteins associated with protein aggregates and oxidatively damaged organelles. These measurements were able to detect the effects of PAHs, and showed a strong relationship with the body burden results. |
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