Detection of ciguatoxin-like and paralysing toxins in Trichodesmium spp. from New Caledonia lagoon |
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| Affiliation: | 1. FB Geowissenschaften, Eberhard Karls-Universität Tübingen, Wilhelmstraße 56, DE-72074 Tübingen, Germany;2. Naturhistoriska riksmuseet, Box 50007, SE-10405 Stockholm, Sweden;3. GZG, Georg-August Universität, Goldschmidtstraße 3, DE-37077 Göttingen, Germany;1. Institut de Recherche pour le Développement (IRD), UMI 209 UPMC UMMISCO, Centre de Recherche Halieutique Méditerranéenne et Tropicale, Avenue Jean Monnet, CS 30171, 34203 Sète cedex, France;2. Institut de Recherche pour le Développement (IRD), Laboratoire d''Excellence LABEX Corail, UR 227 COREUS, BP A5 98848 Nouméa cedex, New Caledonia;3. Institut de Recherche pour le Développement (IRD), UMR 212 EME, Centre de Recherche Halieutique Méditerranéenne et Tropicale, Avenue Jean Monnet, CS 30171, 34203 Sète cedex, France;4. AgroParisTech, F-75005 Paris, France;5. Laboratory of marine biology and ecology, Aquarium des Lagons, 61 promenade Roger Laroque, 98 800 Noumea, New Caledonia;6. Institut de Recherche pour le Développement (IRD), UMR 6539 LEMAR, Institut Universitaire Européen de la Mer, Plouzané, France |
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| Abstract: | Marine pelagic cyanobacteria Trichodesmium are widespread in the New Caledonia lagoon. Blooms of these Oscillatoriales are suspected to be a potential source of toxins in the ciguatera food chain and were previously reported to contain certain types of paralysing toxins. In the present study, toxicity experiments were conducted on lipid- and water-soluble extracts of freeze-dried samples of these cyanobacteria. Lipid-soluble fractions revealed a ciguatoxin-like activity in both in vivo (mouse bioassay) and in vitro (mouse neuroblastoma cells assay and receptor binding assay using tritiated brevetoxin-3) assays. The water-soluble fractions tested on mice exhibited neurotoxicity with paralytic symptoms. These toxicities have also been observed with benthic filamentous cyanobacteria within the Oscillatoriales order, also collected in New Caledonia. This study provides an unprecedented evidence of the toxicity of Trichodesmium species from the New Caledonia lagoon. This survey also demonstrates the possible role of these cyanobacteria in ciguatera fish poisoning. |
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