| 日本刺参的抗肿瘤及免疫调节作用研究 |
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| 引用本文： | 王静凤,王奕,赵林,逄龙,薛长湖.日本刺参的抗肿瘤及免疫调节作用研究[J].中国海洋大学学报(自然科学版),2007,37(1):93-96,102. |
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| 作者姓名： | 王静凤 王奕 赵林 逄龙 薛长湖 |
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| 作者单位： | 1. 中国海洋大学食品科学与工程学院,山东,青岛,266003
2. 中国人民解放军济南军区第456医院,山东,济南,250031 |
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| 基金项目： | 教育部跨世纪优秀人才培养计划;国家自然科学基金 |
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| 摘 要： | 采用日本刺参（Apostichopus japonicus）浆灌胃移植性肿瘤模型小鼠，探讨了日本刺参的抗肿瘤作用及其对免疫功能的调节作用。结果表明，日本刺参各剂量组均能显著抑制小鼠S180肉瘤的生长，提高小鼠脾指数及胸腺指数（P〈0．05）；显著提高荷瘤小鼠血清溶血素含量（P〈0．01）和抗体形成细胞数（P〈0．05）；提高迟发型变态反应水平和脾淋巴细胞转化能力（P〈0．05，P〈0．01）；促进NK细胞活性和巨噬细胞的吞噬能力（P〈0．05。P〈0．01）。提示日本刺参能全面调节机体的特异性和非特异性免疫功能．控制和杀灭肿瘤细胞。
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| 关 键 词： | 日本刺参 抗肿瘤 免疫调节 |
| 文章编号： | 1672-5174（2007）01-093-05 |
| 修稿时间： | 2006-05-242006-10-27 |
Effects of Apostichopus japonicus on Antitumor and Immune Regulation in S180 Bearing Mice |
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| WANG Jing-Feng,WANG Yi,ZHAO Lin,PANG Long,XUE Chang-Hu.Effects of Apostichopus japonicus on Antitumor and Immune Regulation in S180 Bearing Mice[J].Periodical of Ocean University of China,2007,37(1):93-96,102. |
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| Authors: | WANG Jing-Feng WANG Yi ZHAO Lin PANG Long XUE Chang-Hu |
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| Abstract: | The effects of postichopus japonicus on antitumor and immune regulation in transplanted tumor-bearing mice were investigated by oral administration.The results showed that Apostichopus japonicus could inhibit tumor growth in S_(180) bearing mice remarkably,enhance spleen and thymus indexes,increase the hemolysin content(P<0.01) and quantity of antibody-forming cells in vivo(P<0.05),heighten the delayed hypersensitivity level and spleen lymphocyte transformation(P<0.05,P<0.01),promote NK cell activity and the phagocytosis ability of celiac macrophage(P<0.05,P<0.01).It is suggested that Apostichopus japonicus can restrain and kill tumor cells by regulating both specific and non-specific immune functions. |
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| Keywords: | Apostichopusjaponicus antitumor immune function |
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