A significant criterion in evaluating disposal strategies for high-level nuclear waste is the assessment of the isolation capacity for the most radiotoxic radionuclides, the actinides. Important processes pertinent to potential mobilization from the waste forms, retention in secondary phases and migration of actinides in the geochemical environment of the near field of disposal locations are summarized. Criteria are formulated for assessing engineered barrier performance as a geochemical barrier for actinide long-term retention.