Lifetime risk of urothelial carcinoma and lung cancer in the arseniasis-endemic area of Northeastern Taiwan |
| |
| Institution: | 1. Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan;2. Genomics Research Center, Academia Sinica, Taipei, Taiwan;3. School of Public Health, Taipei Medical University, Taipei, Taiwan;4. Graduate Institute of Oncology, National Taiwan University, Taipei, Taiwan;5. Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan;6. Division of Urology, Department of Surgery, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan;7. Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan;8. Management Office for Health Data, China Medical University and Hospital, Taichung, Taiwan;9. Graduate Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan;1. Tan Trao University, Tuyen Quang, Viet Nam;2. VNU University of Science, Ha Noi, Viet Nam;3. Duy Tan University, Da Nang, Viet Nam;1. Laboratory of Infrared Materials and Devices, The Research Institute of Advanced Technologies, Ningbo University, Ningbo, Zhejiang, 315211, China;2. Key Laboratory of Photoelectric Detection Materials and Devices of Zhejiang Province, Ningbo, Zhejiang, 315211, China;3. Laboratoire des Verres et Ceramiques, Universite de Rennes I, Rennes Cedex, 35042, France;1. ENVIRON International Corporation, 1900 N. 18th Street, Suite 804, Monroe, LA 71201, United States;2. ENVIRON International Corporation, 2200 Powell Street, Suite 700, Emeryville, CA 94608, United States;3. The Hamner Institutes for Health Sciences, 6 Davis Drive, Research Triangle Park, NC 27709-2137, United States;4. University of New Mexico, MSC 10 5550, 1 University of New Mexico, Albuquerque, NM 87131-0001, United States;1. Center for Epidemiology and Environmental Health (CEOH, LLC), Washington, DC, 20016, USA;2. Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, 20007, USA;3. Milken Institute School of Public Health, George Washington University, Washington, DC, 20052, USA;4. Department of Biostatistics, Bioinformatics, and Biomathematics, Georgetown University School of Medicine, Washington, DC, 20007, USA;1. Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA;2. Department of Epidemiology and Public Health, Sciensano, Brussels, Belgium;3. Department of Veterinary Public Health and Food Safety, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium;4. Gibb Epidemiology Consulting LLC, Arlington, VA, USA;5. George Washington University Milken Institute School of Public Health, Washington, D.C., USA;6. Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA;7. Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA, USA |
| |
| Abstract: | Arsenic in drinking water has been shown to increase the risk of urothelial carcinoma and lung cancer. However, the lifetime risk of developing urothelial carcinoma and lung cancer caused by exposure to arsenic in drinking water has not been reported. This study aimed to assess the lifetime risk of urothelial carcinoma and lung cancer caused by arsenic exposure from drinking water and cigarette smoking habit for residents living in the arseniasis-endemic area in Northeastern Taiwan. We recruited 8086 residents in 1991–1994 and monitored them for their newly developed types of cancers, identified by computerized linkage with the national cancer registry profile. There were 37 newly diagnosed urothelial carcinoma cases and 223 new lung cancer cases during the follow-up period (until 2007). The lifetime (35–85 years old) cumulative risk of developing urothelial carcinoma from an arsenic concentration in the drinking water of <10, 10–99, and 100+ μg/L was 0.29%, 1.07% and 3.43%, respectively. The corresponding probabilities were 7.42%, 8.99% and 17.09% for the lifetime risk of developing lung cancer. Cigarette smoking was associated with an increased risk of urothelial carcinoma and lung cancer, showing the hazard ratio (95% confidence interval) of 2.48 (1.27–4.82) and 3.44 (2.00–5.90) after adjusting for the arsenic concentration in drinking water. After adjusting for cigarette smoking, the hazard ratio (95% confidence interval) of developing urothelial carcinoma caused by the arsenic concentration in drinking water of <10, 10–99 and 100+ μg/L was 1.0 (the reference group), 2.18 (0.59–8.01), and 8.71 (2.49–30.48), respectively. The corresponding figures were 1.0 (the reference group), 1.14 (0.80–1.61), 1.84 (1.28–2.65) for lung cancer. Synergistic effects on the development of urothelial carcinoma and lung cancer existed between the arsenic exposure level and cigarette smoking. It is suggested that people who have had a high exposure to arsenic in drinking water should stop smoking cigarettes to lower their lifetime risk of urothelial carcinoma and lung cancer. |
| |
| Keywords: | Arsenic Urothelial carcinoma Lung cancer Lifetime risk Cigarette smoking |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
