Diet restriction induced autophagy: a lysosomal protective system against oxidative- and pollutant-stress and cell injury |
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Authors: | Moore Michael N |
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Institution: | Plymouth Marine Laboratory, Prospect Place, The Hoe, Plymouth PL1 3DH, UK. mnm@pml.ac.uk |
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Abstract: | Nutrient deprivation or dietary restriction (DR) confers protection against ageing and stress in many animals and induced lysosomal autophagy is part of this mechanism. The effects of dietary restriction on the toxicity of copper and the polycyclic aromatic hydrocarbon phenanthrene have been investigated in the common marine mussel Mytilus edulis. The findings show that DR-induced autophagy facilitates the recovery of the digestive gland (i.e., molluscan liver analogue) from cell injury caused by both copper and phenanthrene. It is inferred that DR-induced autophagy and lysosomal proteolysis results in improved cellular "housekeeping" through the more efficient removal of oxidatively and pollutant damaged proteins (e.g., protein carbonyls, protein adducts, etc.) and that this contributes to stress resistance. |
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Keywords: | Diet restriction Autophagy Lysosomes Lysosomal proteolysis Pollutants Oxidative-stress Cell injury Stress resistance Mussels |
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