The chemical constituents from red alga Gymnogongrus flabelliformis Harv.

Eight compounds were isolated from red alga Gymnogongrus flabelliformis Harv. In normal phase silica gel, Sephadex LH-20 gel column chromatography, reverse phase HPLC, and recrystallization. Based on MS and ID NMR spectroscopic data, their structures were determined as： stigmast-4-en-3-one （Ⅰ）, cholest-4-en-3-one （Ⅱ）, cholesterol （m）, uracil （Ⅳ）, uridine （V）, adenosine （Ⅵ）, succinic acid （Ⅶ）, and 5-hydroxy-4-methyl-5-pentyl-2,5-dihydro-furan-2-on （Ⅷ）. All of them were obtained from this species for the first time. Cytotoxicity of these compounds was screened using standard MTT method, but all the compounds were inactive （IC50 〉 10 μg/ml）.     

多源卫星观测的全球海洋次表层温度异常信息提取

基于表层卫星遥感观测的中深层海洋遥感对于了解海洋内部异常及其动力过程有重要意义。如何从现有的海洋表层遥感观测资料提取海洋内部关键动力环境信息场是具有挑战性的海洋遥感技术前沿。本文采用支持向量回归(SVR)方法,通过卫星遥感观测获取的多源海表参量(海表高度异常(SSHA)、海表温度异常(SSTA)、海表盐度异常(SSSA)和海表风场异常(SSWA)),选择最优参量输入组合,感知海洋次表层温度异常(STA),并用实测Argo数据作精度验证。结果表明SVR模型可准确估算全球尺度的STA(1000 m深度以浅);当SVR输入变量为2个(SSHA、SSTA)、3个(SSHA、SSTA、SSSA)、4个(SSHA、SSTA、SSSA、SSWA)时对应的平均均方差(MSE)分别为0.0090、0.0086、0.0087,平均决定系数(R2)分别为0.443、0.457、0.485。因此,除了SSHA和SSTA外,SSSA与SSWA的输入对SVR模型的估算有积极影响,有助于提高STA的估算精度。在全球增暖与减缓背景下,该研究可为从表层卫星遥感观测提取海洋内部热力异常信息研究提供重要技术支持,有利于拓展卫星对海观测范围。     

我看到了水星凌日

我看到了水星凌日水星凌日是水星经过日面的天文现象，平均每一百年发生十三次。本世纪最后两次水星凌日是在１９９３年１１月６日和１９９９年１１月１５日发生。１１月３日，我收到载有水星凌日资料的《业余天文快讯》，并参考《天文爱好者》和《天文普及年历》，计算了...     

基于X．25网实现省内地面网络系统互连

沈阳区域气象中心在9210工程中使用IBM路由器,地市气象局采用铁通X.25广域网卡,使省、市局通过X．25线路实现了广域网的互连。建网过程中,积累了一些网络安装、配置、排错等方面的经验。     

细长杆与圆孔孔壁接触碰撞问题的动力间隙元法

本文通过在任意曲率的细长杆节点和圆孔孔壁之间构造一种虚拟单元－－动力间隙元，将任意曲率的细长杆与圆孔孔壁连接起来，使其间的接触碰撞问题转化为平衡方程问题。文中针对石油工程中钻柱这类典型的细长杆与圆形井壁的接触碰撞问题进行了求解。结果表明，动力间隙元能较好地解决细长杆（如钻柱）与圆孔孔壁（如井壁）的接触碰撞问题。     

“960628”黄淮气旋暴雨分析

１９９６年汛前淮河流域首场大暴雨,是在有利的环境背景下,低层低涡切变线发展,诱生地面气旋,形成了一个较深厚的天气尺度暴雨系统。通过对一些物理量分析,得出几点不稳定能量释放和上升运动发展的结论。     

The antitumor effect of bromophenol derivatives <Emphasis Type="Italic">in vitro</Emphasis> and <Emphasis Type="Italic">Leathesia nana</Emphasis> extract <Emphasis Type="Italic">in vivo</Emphasis>

To investigate the antitumor effect of bromophenol derivatives in vitro and Leathesia nana extract in vivo, six bromophenol derivatives 6-(2,3-dibromo-4,5-dihydroxybenzyl)-2,3-dibromo-4,5-dihydroxy benzyl methyl ether (1), (+)-3-(2,3-dibromo-4,5-dihydroxyphenyl)-4-bromo-5,6-dihydroxy-1,3-dihydroisobenzofuran (2), 3-bromo-4-(2,3-dibromo-4,5-dihydroxybenzyl)-5-methoxymethyl-pyrocatechol (3), 2,2′,3,3′-tetrabromo-4,4′,5,5′-tetrahydroxy-diphenylmethane (4), bis(2,3-dibromo-4,5-dihydroxybenzyl) ether (5), 2,2′,3-tribromo-3′,4,4′,5-tetrahydroxy-6′-ethyloxymethyldiphenylmethane (6) were isolated from brown alga Leathesia nana, and their cytotoxicity were tested by MTT assays in human cancer cell lines A549, BGC-823, MCF-7, B16-BL6, HT-1080, A2780, Bel7402 and HCT-8. Their inhibitory activity against protein tyrosine kinase (PTK) with over-expression of c-kit was analyzed also by ELISA. The antitumor activity of ethanolic extraction of Leathesia nana (EELN) was evaluated on S₁₈₀-bearing mice. All compounds showed very potent cytotoxicity against all of the eight cancer cell lines with IC₅₀ below 10 μg/mL. In PTK inhibition study, all bromophenol derivatives showed moderate inhibitory activity and compounds 2, 5 and 6 showed significant bioactivity with the inhibition ratio of 77.5%, 80.1% and 71.4%, respectively. Pharmacological studies reveal that EELN could inhibit the growth of Sarcoma 180 tumor and increase the indices of thymus and spleen to improve the immune system remarkably in vivo. Results indicated that the bromophenol derivatives and EELN can be used as potent antitumor agents for PTK over-expression of c-kit and considered in a new therapeutic strategy for treatment of cancer. Supported by the National High Technology Research and Development Program of China (863 Program, No. 2007AA09Z410) and Knowledge Innovation Program of Chinese Academy of Sciences (No. KZCX2-YW-209)