基于生物信息学探讨骨质疏松症与2型糖尿病的关系

目的：基于生物信息学探讨骨质疏松症与 2 型糖尿病的关系。方法：通过基因表达汇编（GEO）数据库检索骨质疏松症和2型糖尿病的相关数据集,并筛选骨质疏松症-2型糖尿病共同差异表达基因,将数据导入STRING数据库找寻关键基因,以一个单细胞测序数据集作为检验集验证关键基因细胞层面的表达水平,对筛选结果进行基因本体（GO）功能及京都基因与基因组百科全书（KEGG）通路富集分析,并对关键靶点、相关中药进行频数统计及功效分类。结果：骨质疏松症与 2 型糖尿病相关通路集中在 ErbB信号通路、丝活化蛋白激酶（MAPK）信号通路、神经营养素信号通路、NOD样受体信号通路。频数统计结果显示,与骨质疏松症-2型糖尿病关键基因相关的中药有51味,以功效分类,可分为清热解毒药、止痛药、祛风药、补虚药、止呕药。结论：骨质疏松症和2型糖尿病都是复杂的代谢性疾病,涉及众多基因表达网络和信号通路。尽管两种疾病存在复杂的基因网络背景,但是分析结果表明两种疾病之间仍存在高度重合的差异基因表达和信号通路。这表明两种疾病的分子机制密切相关,可能存在共同调控的靶点,因此这些靶点可能成为药物同时干预两种疾病的治疗靶点。     

登陆我国热带气旋活动的年代际变化分析

本文利用1950－1999年西北太平洋热带气旋资料，对50年来登陆我国热带气旋的月际、年际和年代际变化及异常情况进行了统计分析，指出了登陆我国的热带气旋频数存在明显的年代际差异，并对比分析了同期的副热带高压等海洋大气环流指数的统计特征。     

A New Pursuit Mode of Nonlinear Wave Surface

The numerical mode of nonlinear wave transformation based on both the Laplace equation for water field and the Bemoulli equation for water surface is a kind of time-domain boundary problem with initial conditions. And the basis for establishing the numerical mode of nonlinear wave in time domain is to trace the position of wave free surface and to calculale the instantaneous surface height and surface potential function. This paper firstly utilizes the ‘0-1‘ combined BEM to separate the boundary by means of discretization of Green‘ s integral equation based on the Laplace equation, then separates the free surface of wave with FEM and derives the FEM equation of wave surface that satisfies the nonlinear boundary conditions. By jointly solving the above BEM and FEM equations, the wave potential and surface height could be obtained with iteration in time domain. Thus a new kind of nonlinear numerical mode is established for calculating wave transformation. The wave test in the numerical wave tank shows that the numerical simulation with this mode is of high accuracy.     

广西主要港湾余流特征及其对物质输运的影响

广西5个主要海湾各有自己的环流特征：铁山湾存在一个反气旋涡，廉州湾存在一个海湾尺度的气旋环流，钦州湾青菜头南端存在一个气旋式环流，防城湾口有一个气旋环流。珍珠湾余流，在深水航道内自湾内指向湾外。冬季，受北风影响，各湾从湾内流向湾外的余流分量加强。由于反气旋或气旋环流存在，形成和环流相应的泥沙输运。     

基于雷达海冰图像互相关的冰漂流场测量

我国的渤海和黄海北部在每年冬季都出现不同程度的冰情,它直接影响结冰海区的石油平台、船舶以及港口等设施的正常作业,对海冰的观测与预报随着上述海区的开发利用越发显得重要,利用航海雷达连续准确地跟踪海冰漂移运动轨迹,是当今观测、调查、研究冰漂流移动规律的有效方法之一,我国的科研人员利用雷达成像技术对渤海的冰情进行了长期的雷达海冰观测、研究,在由雷达海冰图像对海冰的物理特征的识别、分类以及冰漂流场测量方面取得了一些进展[1-4]。     

冬季和春季长江口及其近海水域浮游病毒丰度的分析

采用荧光显微技术,对2006年长江口及近海水域20个站点的表层及10m层或潜水体冬、春两季的浮游病毒丰度进行了检测,对浮游病毒丰度在季节（冬、春两季）、水平分布和垂直分布上的变化进行了探讨.调查区浮游病毒丰度在冬、春季节上并无明显差异,但在水平分布上存在很大差异,河口区浮游病毒直接检测量（Virus Direct Count, VDC）达到10^7个/ml,近海水域VDC为10^6个/ml,河口区的浮游病毒丰度都明显高于近海水域病毒丰度 （P＜0.01）.在垂直分布上,冬、春两季长江口水域水深小于10m的站位,表层浮游病毒丰度与底层病毒丰度无明显差别,水深大于10m的站位,表层水样的浮游病毒丰度都高于10m水层病毒丰度,说明长江口浮游病毒的垂直分布与站位总水深有关.还通过比较各站点VDC与叶绿素a含量的数据,分析了二者之间的相关性：冬季浮游病毒丰度与叶绿素a含量成正相关性;春季浮游病毒丰度与叶绿素a含量成负相关性,但病毒丰度受叶绿素a含量的影响仅为10%-11%.     

Second-order random interfacial wave solutions for two-layer fluid with a free surface

1 Introduction Interfacial waves travelling along the interface between two fluids of different densities can be often observed in subsurface layers of the ocean since the upper subsurface layer is warmer over much of the o- cean (Umeyama, 2002). They are…     

海洋沉积物声速与物理参数的关系

海洋沉积声速与物理性质密切相关，特别是含水量Ｗ和孔隙度Ｎ，它们在建立回归议程和预报沉积物性质中有所贡献。中国东，南海沿海沉积物的资料和数据表明：声速和声速比可以用来预报沉积物性质。     

苏北盆地中古生代油气勘探发现与生储盖组合特征及现实意义

苏北盆地中古生代油气勘探具有50年的历史,在收集前人资料分析基础上,对苏北盆地和黄桥二氧化碳气田及朱家墩天然气田生储盖体系的地质特征及成藏要素分别进行了对比,分析了典型成藏模式;认为苏北盆地虽然只是苏北—南黄海盆地古、中、新生代盆地的一小部分,但其幔源"古生新储"二氧化碳气田和常规"古生新储"天然气田的发现对于海域南黄海盆地极具现实意义。     

VERIFICATION OF INTERNAL WAVES IN OFFSHORE AREAS BY MEANS OF CURRENT OBSERVATIONS

Based on the shear effect of internal wave currents in stratified fluid, the necessary condition for the possible existence of an internal wave and the sufficient condition under which there will be no internal wave are deduced starting from the continuity equation of incompressible fluid. The above two conditions are verified by the measured results from vertical current meter arraies at some observation stations in the Bohai Sea and the South Huanghai Sea. In the treatment of measured results, first of all, the tidal period components are separated from the measured currents by Fourier-analysis method, and then the internal wave currents of tidal period from the tidal period components in the light of some considerations. The analytical results of observed currents are well consistent with theoretical analysis. Furthermore, one can also deduce some features of internal waves therefrom. Consequently, it is concluded that the observation from a vertical current meter array is an important means to verif