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991.
We extracted marine low-temperature lysozyme (MLTL), a novel lysozyme, from a marine microorganism through fermentation. Our
previous study suggested that a low molecular weight (16 kDa) may exert anti-tumor activity through antiangiogenesis. In this
study, we extracted a high weight (39 kDa) and investigated its antiangiogenic activity in vivo and in vitro. Using zebrafish embryos as an in vivo study model, we found that treatment with MLTL significantly inhibited the growth of subintestinal vessels (SIVs) in a dose-dependent
manner and that 400 μg/ml MLTL was sufficient to block the growth of SIVs. An in vitro study conducted using human umbilical vein endothelial cells (HUVECs) revealed that MLTL suppressed the proliferation, migration
and tube formation of HUVECs in a dose-dependent manner. Interestingly, assays by flow cytometry and DNA electrophoresis indicated
that MLTL was able to induce apoptosis of HUVECs. Moreover, further study demonstrated that the disruption of intracellular
Ca2+ homeostasis may play an important role in MLTL induced apoptosis of HUVECs. Taken together, the results of this study demonstrate
for the first time that MLTL inhibits angiogenesis through its pleiotropic effects on vascular endothelial cells and induces
apoptosis through regulation of cellular Ca2+ levels. The results of this study also revealed a possible mechanism underlying the antiangiogenic effect of MLTL and suggested
that MLTL may be a promising new antiangiogenic agent for use in cancer therapy. 相似文献
992.
Expression of putative zinc-finger protein lcn61 gene in lymphocystis disease virus China (LCDV-cn) genome 总被引:1,自引:0,他引:1
An open reading frame (lcn61) of lymphocystis disease virus China (LCDV-cn), probably responsible for encoding putative zinc-finger proteins was amplified
and inserted into pET24a (+) vector. Then it expressed in E. coli BL21 (DE3), and His-tag fusion protein of high yield was obtained. It was found that the fusion protein existed in E. coli mainly as inclusion bodies. The bioinformatics analysis indicates that LCN61 is C2H2 type zinc-finger protein containing
four C2H2 zinc-finger motifs. This work provides a theory for functional research of lcn61 gene.
Supported by High Technology Research and Development Program of China (863 Program, No. 2006AA100309) 相似文献
993.
The Yiluo River is the largest tributary for the middle and lower reaches of the Yellow River below Sanmenxia Dam. Changes of the hydrological processes in the Yiluo River basin, influenced by the climatic variability and human activities, can directly affect ecological integrity in the lower reach of the Yellow River. Understanding the impact of the climatic variability and human activities on the hydrological processes in the Yiluo River basin is especially important to maintain the ecosystem integrity and sustain the society development in the lower reach of the Yellow River basin. In this study, the temporal trends of annual precipitation, air temperature, reference evapotranspiration (ET0) and runoff during 1961–2000 in the Yiluo River basin were explored by the Mann‐Kendall method (M‐K method), Yamamoto method and linear fitted model. The impacts of the climatic variability and vegetation changes on the annual runoff were discussed by the empirical model and simple water balance model and their contribution to change of annual runoff have been estimated. Results indicated that (i) significant upwards trend for air temperature and significant downwards trend both for precipitation and ET0 were detected by the M‐K method at 95% confidence level. And the consistent trends were obtained by the linear fitted model; (ii) the abrupt change started from 1987 detected by the M‐K method and Yamamoto method, and so the annual runoff during 1961–2000 was divided into two periods: baseline period (1961–1986) and changeable period (1987–2000); and (iii) the vegetation changes were the main cause for change of annual runoff from baseline period to changeable period, and climatic variability contributed a little to the change of annual runoff of the Yiluo River. Copyright © 2009 John Wiley & Sons, Ltd. 相似文献
994.
Journal of Geographical Sciences - With the rapid development of knowledge economy, a number of important shifts are emerging in urbanization pattern across the world. Traditional urbanization... 相似文献
995.
基于多源遥感数据的区域生态系统服务价值年际动态监测 ——以中原城市群为例 总被引:2,自引:0,他引:2
通过对多源遥感数据在生态系统服务价值(ESV)遥感模型中的尺度效应分析,选择满足最佳空间分辨率和长时间序列的遥感数据,对中原城市群区域2001~2013年的ESV实现了逐年逐像元水平的动态监测。结果表明:该区应用于遥感模型输入数据的最适空间分辨率为30~1 000 m,相对于30 m尺度,其他尺度估算结果的相对偏差均小于0.4%;结合年际动态监测的需求,选择了MODIS数据产品(空间分辨率500 m,时间尺度1 a)作为遥感模型的最佳数据源;研究区ESV总值在研究期内整体上呈显著增长趋势,增速约为8.6亿元/a,但在持续增长过程中经历了3次波动,且表现得越来越剧烈;在空间上,研究区ESV多年均值呈现出明显的不均衡性,表现为从西南向东部递减的趋势。研究表明此方法简单易行,初步实现了区域ESV年际动态监测遥感模型的准业务化运行。 相似文献
996.
Examining the sensitivity of spatial scale in cellular automata Markov chain simulation of land use change 总被引:2,自引:0,他引:2
Hao Wu Zhen Li Keith C. Clarke Wenzhong Shi Anqi Lin 《International journal of geographical information science》2019,33(5):1040-1061
Understanding the spatial scale sensitivity of cellular automata is crucial for improving the accuracy of land use change simulation. We propose a framework based on a response surface method to comprehensively explore spatial scale sensitivity of the cellular automata Markov chain (CA-Markov) model, and present a hybrid evaluation model for expressing simulation accuracy that merges the strengths of the Kappa coefficient and of Contagion index. Three Landsat-Thematic Mapper remote sensing images of Wuhan in 1987, 1996, and 2005 were used to extract land use information. The results demonstrate that the spatial scale sensitivity of the CA-Markov model resulting from individual components and their combinations are both worthy of attention. The utility of our proposed hybrid evaluation model and response surface method to investigate the sensitivity has proven to be more accurate than the single Kappa coefficient method and more efficient than traditional methods. The findings also show that the CA-Markov model is more sensitive to neighborhood size than to cell size or neighborhood type considering individual component effects. Particularly, the bilateral and trilateral interactions between neighborhood and cell size result in a more remarkable scale effect than that of a single cell size. 相似文献
997.
The topographical suitability assessment of human settlements(SAHS) creates a solid foundation for regional population distribution and socio-economic development. Local elevation range(LER) is an important factor that can be used to assess the suitability of different terrains for sustaining human settlements. However, current digital elevation model(DEM)-based LER products suffer from some challenges typically because of their subjectively selected neighborhood scales and coarser spatial resolution. In this study, we initially determined the optimal statistical window and then calculated the appropriate LER with the finer resolution data of the Advanced Spaceborne Thermal Emission and Reflection Radiometer Global DEM(ASTER GDEM) products for China. Then, the appropriate LER was used to evaluate the topographical SAHS and its correlations with the national gridded population distribution(1 km × 1 km) in 2010. The results show that the optimal statistical window for calculating a 1 arc-second(about 30 m) resolution GDEM LER for China can be determined using a 51 × 51 grid unit(width × height) within a rectangular neighborhood, corresponding to an area of about 2.34 km~2. Secondly, the LER values in the southern and western China were greater than those of the north and east, showing a trend which consistently reflects the general spatial features of landforms. Finally, the relationship between GDEM LER and population density was highly correlated with the R~2 value of 0.81. It showed that 85.22% of the Chinese population was located in areas where the LER is lower than 500 m. The topographically suitable area within China decreased from the southeastern coastal zone towards the northwestern inland areas due to transition from plains and basins to plateaus and mountains. The total area of moderate to high suitable level was 423.84 × 10~4 km~2, or 44.15% of the total land area, with 88.17% of the national population. Our study demonstrates the usefulness of appropriate LER in evaluating the topographical SAHS as well as its significant impact on population distribution. 相似文献
998.
As an important physical process at the air-sea interface, wave movement and breaking have a significant effect on the ocean surface mixed layer (OSML). When breaking waves occur at the ocean surface, turbulent kinetic energy (TKE) is input downwards, and a sublayer is formed near the surface and turbulence vertical mixing is intensively enhanced. A one-dimensional ocean model including the Mellor-Yamada level 2.5 turbulence closure equations was employed in our research on variations in turbulent energy budget within OSML. The influence of wave breaking could be introduced into the model by modifying an existing surface boundary condition of the TKE equation and specifying its input. The vertical diffusion and dissipation of TKE were effectively enhanced in the sublayer when wave breaking was considered. Turbulent energy dissipated in the sublayer was about 92.0% of the total depth-integrated dissipated TKE, which is twice higher than that of non-wave breaking. The shear production of TKE decreased by 3.5% because the mean flow fields tended to be uniform due to wave-enhanced turbulent mixing. As a result, a new local equilibrium between diffusion and dissipation of TKE was reached in the wave-enhanced layer. Below the sublayer, the local equilibrium between shear production and dissipation of TKE agreed with the conclusion drawn from the classical law-of-the-wall (Craig and Banner, 1994). 相似文献
999.
无限水深聚焦波完全非线性数值模拟 总被引:1,自引:1,他引:0
基于势流理论提出一种新的高阶边界元方法对无限水深的聚焦波浪进行完全非线性数值模拟.自由水面满足完全非线性边界条件,模拟波浪的非线性效果可以达到更高阶.利用镜像原理,建立一种全新的格林函数应用到无限水深的数值波浪水槽中,以致于两无限深水槽侧壁的积分可以被排除.为了产生相应的入射波和吸收出流波浪,一个由点源组成的造波装置被布置于计算域内,同时人工阻尼层被用来吸引出流波浪,由波浪聚焦的方法得到极限波浪.通过开展线性和完全非线性聚焦波浪的数值实验及与理论解对比,验证本数值模型可以用来模拟无限深水域的极限波浪,且在出流边界没有反射. 相似文献
1000.
��Ӷ��Ѵ������ֽ�������ЧӦ 总被引:1,自引:1,他引:0
????????????????????????β??????????????1985??2006??β?????仯??????????1???????????????????????????????????????????????????????????????????????????2????????????????????????????????1?λ??????????£??????????ε?????????????????????1?γ????????仯?????3?? ????????????????仯?????????????????仯???????????????????????????? 相似文献