Synthesis and protein tyrosine phosphatase 1B inhibition activities of two new synthetic bromophenols and their methoxy derivatives

3-bromo-4,5-bis(2,3-dibromo-4,5-dihydroxybenzyl)-1,2-benzenediol (1) is a natural bromophenol isolated from the red algae Rhodomela confervoides that exhibits significant inhibition against protein tyrosine phosphatase 1B (PTP1B). Based on its activity, we synthesized two new synthetic bromophenols and their methoxy derivatives from vanillin using the structure of natural bromophenol 1 as a scaffold. The structures of these bromophenols were elucidated from 1H NMR, 13C NMR, and high resolution electron ionization mass spectrometry as 2,3-dibromo-1-(2p-bromo-6p-(3q,4q-dimethoxybenzyl)- 3p,4p-dimethoxybenzyl)-4,5-dimethoxybenzene(2),2,3-dibromo-1-(2p-bromo-6p-(2q-bromo-4q,5q-dimethoxy-benzyl)-3p,4p-dimethoxybenzyl)-4,5-dimethoxybenzene(3),3,4-dibromo-5-(2p-bromo-6p-(2q-bromo-4q,5q-dihydroxybenzyl)-3p,4p-dihydroxybenzyl)pyrocatechol(4)and 3,4-dibromo-5-(2p-bromo-6p-(3q,4q-dihydroxybenzyl)-3p,4p-dihydroxybenzyl)pyrocatechol (5).PTP1B inhibition activities of these compounds were evaluated using a colorimetric assay,and compounds 3 and 4 demonstrated interesting activity against PTP1B.     

Effects of alginate gel on rheological properties of hair-tail (Trichiurus lepturus) surimi

Effects of alginate gel at different concentrations on rheological properties of hair-tail (Trichiurus lepturus) surimi were investigated. Alginate gel (1% - 3%) exhibited enhanced effects, especially when alginate gel concentration increased. The rheological properties of mixture samples were studied by the time sweep, frequency sweep and temperature sweep. The critical strain values of the mixture samples for the onset of non-linear viscoelasticity were about 5%. The storage modulus G’ of the mixture samples increased with time for 4 h. The frequency sweep showed that G’ was greater than G" for all the mixture gels with different alginate gel concentrations, and values of both n’ and n" for all samples were low (<0.2), these constants corresponding to G’ and G", and indicating the elasticity of mixture gels. The values of storage modulus G’ decreased during heating process and increased with decreasing temperature.     

Change of ancient hydrology net in Northeast China Plain

Comparing with lithofacies palaeogeography of several great plains, the authors analyzed four great plains in Quaternary diastrophism, the sedimentary facies, sedimentary environment and their evolution from the independent embryonic and river system of ancient Heilongjiang finally to the Halar highland, Songnen Plain, Sanjiang Plain, the Xingkai Lake Plain and various river systems, collected the unification outside the system of Heilongjiang River to release into the sea, south ancient Xialiao River finally piracy Dongliao River, Xialiao River had released into the sea the ancient water law vicissitude and the evolved rule.     

Change of ancient hydrology net in Northeast China Plain

Comparing with lithofacies palaeogeography of several great plains,the authors analyzed four great plains in Quaternary diastrophism,the sedimentary facies,sedimentary environment and their evolution from the independent embryonic and river system of ancient Heilongjiang finally to the Halar highland,Songnen Plain,Sanjiang Plain,the Xingkai Lake Plain and various river systems,collected the unification outside the system of Heilongjiang River to release into the sea,south ancient Xialiao River finally piracy Dongliao River,Xialiao River had released into the sea the ancient water law vicissitude and the evolved rule.     

RELATIONSHIP BETWEEN QINGHAI LAKE LEVEL DESCENDING AND ARTIFICIAL WATER－CONSUMPTION

ＲＥＬＡＴＩＯＮＳＨＩＰＢＥＴＷＥＥＮＱＩＮＧＨＡＩＬＡＫＥＬＥＶＥＬＤＥＳＣＥＮＤＩＮＧＡＮＤＡＲＴＩＦＩＣＩＡＬＷＡＴＥＲ－ＣＯＮＳＵＭＰＴＩＯＮ￥ＰｅｎｇＭｉｎ（彭敏）ＣｈｅｎＧｕｉｃｈｅｎ（陈桂琛）ＺｈｏｕＬｉｈｕａ（周立华）（Ｎｏｒｔｈｗｅ...     

A singular spectrum analysis on Holocene climatic oscillation from lake sedimentary record in Minqin Basin, China

The total organic carbon (TOC) content series from the lake sediment of Minqin Basin (100°57′–104°57′E, 37°48′–39°17′N) in northwestern China, which has a 10 000-year-long paleo-climatic proxy record, was used to analyze the Holocene climate changes in the local region. The proxy record was established in the Sanjiaocheng (SJC), Triangle Town in Chinese, Section (103°20′25″E, 39°00′38″N), which is located at the northwestern boundary of the present Asian summer monsoon in China, and is sensitive to global environmental and climate changes. Applying singular spectrum analysis (SSA) to the TOC series, principal climatic oscillations and periodical changes were studied. The results reveal 3 major patterns of climate change regulated by reconstructed components (RCs). The first pattern is natural long-term trend of climatic change in the local area (Minqin Basin), indicating a relatively wetter stage in early Holocene (starting at 9.5 kaBP), and a relatively dryer stage with a strong lake desiccation and a declined vegetation cover in mid-Holocene (during 7–6 kaBP). From 4.0 kaBP to the present, there has been a gradually decreasing trend in the third reconstructed component (RC3) showing that the local climate changed again into a dryer stage. The second pattern shows millennial-centennial scale oscillations containing cycles of 1 600 and 800 years that have been present throughout almost the entire Holocene period of the last 10 000 years. The third pattern is a millennial-centennial scale variation with a relatively smaller amplitude and unclear cycles showing a nonlinear interaction within the earth’s climate systems.     

LAND COVER CHANGES AND LANDSCAPE DYNAMICS ASSESSMENT IN LOWER REACHES OF TARIM RIVER IN CHINA

The Tarim River Basin, located in the typical arid region, is one of the key regions of LUCC research in China and plays an important role in maintaining the sustainable development of the westem China. In recent years, the ecological environment of the Tarim River Basin has degraded greatly. In the lower reaches, in particular,the riverbed has been dried up for more than 20 years, which accelerated the desertification and has been a great threat to people‘s lives. Taking the section of the Tarim River between Qiala Lake and Taitema Lake as a typical region, an investigation on land cover changes was carried out with the support of remote sensing information of 1988 and 2000 respectively. The changes of land cover in this region were obtained: 1) Cropland tended to increase. 2)Urban or Built-up Area in 2000 was 324.4ha more than that in 1988.3) Waters expanded by 3476.51ha. 4) Woodland and Grassland decreased, while Barren Land increased by 3824.9ha. The total amount of land use/land cover change between 1988 and 2000 is small, which is only 0.355% of the total area. It shows that the developmental pace of the lower reaches of the Tarim River is relative slow. Based on these results, the authors assessed the landscape dynamics of this region and pointed out that the degree of desertification was strengthened and the landscape dominated by sand land was further characterized by salt desert.     

“海上丝绸之路”沿线重要港口区位优势度评估

评估“海上丝绸之路”沿线港口的区位优势度,对于港口及其腹地基础设施合理规划、港口未来投资预判以及推进“一带一路”倡议有重要意义。本文从海陆联运的视角出发,综合考虑港口腹地的路网密度、交通干线影响度、城市影响度、航运战略枢纽影响度和航运战略通道影响度等五个因素,构建港口区位优势度评价模型来对“海上丝绸之路”沿线重要港口进行区位优势度分析。研究发现：① “海上丝绸之路”沿线港口的区位优势度区域化差异显著,从东向西总体呈“高-低-高”的空间分布格局;② 从世界分区的视角看,东南亚区域港口区位优势最高,其次为南欧至西欧、南亚、北非、西亚等地区,东非至南非区域港口区位优势度最低;③ 港口各区位影响因素的评价结果空间分布特征差异显著,其中港口区位优势度分布特征与交通干线影响度、城市影响度的相关性较大。研究结果可为海外港口基础设施的投资建设过程提供科学支撑。     

Extraction of organochlorine pesticides in sediments using soxhlet,ultrasonic and accelerated solvent extraction techniques

The application of soxhlet, ultrasonic and accelerated solvent extraction techniques to the analysis of six organochlorine pesticides (α-HCH, β-HCH, γ-HCH, o, p'-DDT, p,p'-DDT and p, p'-DDE) in Taihu Lake sediment samples is described. It was found that the limits of quantification ranged from 0.002μgg-1 to 0.004μgg-1, and the recoveries of organochlorine pesticides with the three extraction techniques were acceptable (>80.7%). With a mass selective detector, better results were obtained by accelerated solvent extraction using hexane-acetone (1:1) as compared with soxhlet and ultrasonic extraction. It was shown that the accelerated solvent extraction was the optimum technique for the analysis of organochlorine pesticides in sediments. The general features of the three extraction techniques are also presented.     

Development and Applications of Dome A-DEM in Antarctic Ice Sheet

Dome A, the highest dome of East Antarctic Ice Sheet, is being an area focused by international Antarctic community after Chinese Antarctic Expedition finally reached there in 2005, and with the ongoing International Polar Year (IPY) during August 2007. In this paper two data processing methods are used together to generate two 100-m cell size digital elevation models (DEMs) of the Dome A region (Dome A-DEM) by using Cokriging method to interpolate the ICESat GLAS data, with Ihde-DEM as a constraint. It provides fundamental data to glaciological and geophysical investigation in this area. The Dome A-DEM was applied to determining the ice-sheet surface elevations and coordinates of the south and north summits, defining boundaries of basins and ice flowlines, deducing subglacial topography, and mapping surface slope and aspect in Dome A region. The DEM shows there are two (north and south) summits in Dome A region. The coordinate and the surface elevation of the highest point (the north summit) are 80°21′29.86″S, 77°21′50.29″E and 4092.71±1.43m, respectively. The ice thickness and sub-ice bedrock elevation at north summit are 2420m and 1672m, respectively. Dome A region contains four drainage basins that meet together near the south summit. Ice flowlines, slope and aspect in detail are also derived using the DEM.     

NUTRIENTS NEAR THE ARCTIC POLE REGION

The distributions of SiO_3-Si, PO_4-P, NO_3-N and NO_2-N concentrations in the seawater, iceand snow from 82°45′21″W, 88°01′20″N to the North Pole are reported and the exchange of thenutrients among the seawater, ice and snow are discussed. The average concentrations of the nutrients inthe seawater near the North Pole were 4.9±2.4μmol/L for SiO_3-Si; 0.60±0.10μmol/L for PO_4-P,3.4±1.7μmol/L for NO_3-N and 0.13±0.04μmol/L for NO_2-N. The nutrient concentrations inthe ice and snow in the North Pole were 0.20 and 0.65μmol/L for SiO_3-Si; 0.22 and 0.25μmol/L forPO_4-P; 1.6 and 5.8μmol/L for NO_3-N, 0.19 and 0.15μmol/L for NO_2-N.     

THE DISTRIBUTION PATTERNS OF BACTERIA,ATP AND THE RELATIONS WITH RESPIRATION RATES AND PHYTOPLANKTON IN THE CHANGJIANG ESTUARY AND ITS ADJACENT EAST CHINA SEA

Two cruises were conducted in January and July 1986 in the Changjiang (Yangtse River) Estuary and its adjacent East China Sea (30°45′ -32°00′N,121°00′-124°00′E). Direct epifluorescence counts of planktonic bacteria and determinations of ATP concentrations were made. Subsamples were taken for measurement of oxygen consumption rates and chlorophyll concentrations.Bacteria and ATP concentrations were higher in summer than in winter, highest in the river and the river mouth, and gradually lower offshore. The bacteria number was correlated positively with suspended matter, nitrates and oxygen consumption rates, and negatively with salinity.In winter bacteria were the main contributors of ATP and the main consumers of dissolved oxygen in the whole studied area. In summer two maxima of ATP were found along the salinity gradient. The first one which coincided with the peak of turbidity near the river mouth was attributed to bacte -ria, and the second which occurred in the waters with a salinity range be     

Feasibility Comparison of Reanalysis Data from NCEP-Ⅰ and NCEP-Ⅱ in the Himalayas

Mt. Everest is often referred to as the earth＇s ＇third＇ pole. As such it is relatively inaccessible and little is known about its meteorology. In 2005, an automatic weather station was operated at North Col （28°1′ 0.95＂ N, 86°57′ 48.4＂ E, 6523 m a.s.l.） of Mt. Everest. Based on the observational data, this paper compares the reanalysis data from NCEP/NCAR （hereafter NCEP-Ⅰ） and NCEP-DOE AMIP-Ⅱ （NCEP- Ⅱ）, in order to understand which reanalysis data are more suitable for the high Himalayas with Mr. Everest region. When comparing with those from the other levels, pressure interpolated from 500 hPa level is closer to the observation and can capture more synoptic-scale variability, which may be due to the very complex topography around Mt. Everest and the intricately complicated orographic land-atmosphereocean interactions. The interpolation from both NCEP-Ⅰ and NCEP-Ⅱ daily minimum temperature and daily mean pressure can capture most synopticscale variability （r〉0.82, n=83, p〈0.001）. However, there is difference between NCEP-Ⅰ and NCEP-Ⅱ reanalysis data because of different model parameterization. Comparing with the observation, the magnitude of variability was underestimated by 34.1%, 28.5 % and 27.1% for NCEP-Ⅰ temperature and pressure, and NCEP-Ⅱ pressure, respectively, while overestimated by 44.5 % for NCEP-Ⅱ temperature. For weather events interpolated from the reanalyzed data, NCEP-Ⅰ and NCEP-Ⅱ show the same features that weather events interpolated from pressure appear at the same day as those from the observation, and some events occur one day ahead, while most weather events and NCEP-Ⅱ temperature interpolated from NCEP-Ⅰ happen one day ahead of those from the observation, which is much important for the study on meteorology and climate changes in the region, and is very valuable from the view of improving the safety of climbers who attempt to climb Mt. Everest.     

A preliminary study on quaternary glacial landforms in Mt.Ma’an

Mt.Ma’an (4288 m) is the highest mountain in the southwest edge of Sichuan Basin. It is situated to the south of the Dadu River. The geographic coordinates are: 28°58′N, 102°55′E. There are six peaks over 4000 m in elevation. Many quaternary glacial landforms in this mountain have been discovered. It’s a typical example of fossil glacial landform in the east China. Its glacial stages are the last glaciation (Q ₃ ³ ) and the neoglaciation (Q ₄ ³ ). Mt. Ma’an and Mt. Luoji (4359 m) are similar in the fossil glacial landforms, but there are still some differences between them. For example, the ratio between the direct difference and the minus difference is different.     

GEOGRAPHIC ENVIRONMENT CHANGE AND FLOOD CATASTROPHE IN HUAIHE RIVER BASIN DURING LAST 2000 YEARS

ＧＥＯＧＲＡＰＨＩＣ ＥＮＶＩＲＯＮＭＥＮＴ ＣＨＡＮＧＥ ＡＮＤ ＦＬＯＯＤ ＣＡＴＡＳＴＲＯＰＨＥ ＩＮ ＨＵＡＩＨＥ ＲＩＶＥＲ ＢＡＳＩＮ ＤＵＲＩＮＧ ＬＡＳＴ ２０００ ＹＥＡＲＳＹａｎｇＤａｙｕａｎ（杨达源）（ＤｅｐａｒｔｍｅｎｔｏｆＧ...     

中国明、清时期黄河和京杭大运河地图的特征与价值

黄河是中华民族的母亲河,而京杭大运河则担负着河运的重要职责,其重要性决定了古代关于黄运工程及其治理的地图数量繁多。本文旨在通过对大量明、清时期黄河、京杭大运河水利地图的梳理,对明、清时期水利地图的载体形式、表现形式和绘制特点进行剖析,并探讨其在地理学、地图学、水利学方面的应用价值和研究价值。明、清时期的黄河、京杭大运河地图,从载体形式来分,主要分为水利典籍（志书、图说）附图和绘本舆图2类：前者多为示意性地图,画法比较简单,只起到辅助说明水利典籍的作用;后者多采用山水形象画法绘制,多为长卷展开景物再现式地图,其主要特点是形象直观。其采用的“对景法”地图表现形式（即所绘黄河、京杭大运河两岸各类地物要素均朝向河流中心线）,容易引起读者的视觉共鸣,轻松构筑被描画事物的整体画面。从表现形式和绘制特点来看,明、清时期还出现了另外2类地图：计里画方类地图和经纬度实测地图,但由于其实用性和艺术性不如山水形象画法地图,因此,这2类地图在明、清并没有得到广泛普及。但从功能和价值而言,不论是长卷展开式古地图、计里画方类古地图,还是经纬度实测地图,对于古地图史、历史地理学、古代水利研究,对如今的地图、水利、地理学研究等,都是不可多得的历史瑰宝。     

Study on fluxes of CH4 emission from paddy fields in Changchun area

Little has been done in measurement and research of the flux of CH₄ emission from paddy fields in Changchun area, Jilin Province, China before 1994. So the purpose of the study is to offer available regional data of CH₄ emission flux and to discuss the factors which affect CH₄ emission from paddy fields. Experimental paddy fields are chosen using TM pictures respectively in Xinlicheng (43°49′N, 125°20′E) of the Yitong River’s and in Wanchang (43°44′10″N, 125°53′11″E) of the Yinma River’s alluvial plain. The fluxes of CH₄ emission from paddy fields are measured by the method of static chamber in Changchun area in 3 consecutive years. The research results show that the peak of CH₄ emission from paddy fields occurs during the booting stage. The mean fluxes of CH₄ emission are 7.056 mg/m(² · h) and 0.489 mg/(m² · h) in the paddy fields of flood and discontinuous irrigation respectively. The contrastive study holds that climate condition, the way of water management and fertilizer variation have significant influence on fluxes of CH₄ emission from paddy fields. The difference of climatic conditions causes the interannual change of the flux of CH₄ emission from paddy fields. In general, the flux of CH₄ emission from paddy fields of flood irrigation is greater than that from paddy fields of discontinuous irrigation. To change the way of water management perhaps in an available way to reduce CH₄ emission flux from paddy fields. Foundation item: Under the auspices of Jilin Commttee of Science and Technology (grant 963416 - 1), and Changchun Jingyuetan Remote Sensing Test Site of the Chinese Academy of Sciences (grant 9504). Biography: YAN Min-hua (1964 -), female, a native of Liaoning Province, master, associate professor. Her research interests include climate change, greenhouse gases and wetland climate.     

“海上丝绸之路”沿线重要港口竞争力评价

“海上丝绸之路”是促进亚欧和亚非互联互通的重要通道,对其沿线重要港口的竞争力研究,可以为海上丝绸之路的建设提供参考。本文综合考虑港口的自然条件、腹地环境、基础设施、服务水平、政府廉洁度,及其在航运网络中的地位差别等因素,运用熵权-层次分析法对沿线51个国家的99个重要港口的竞争力进行评价。结果表明,① 港口综合竞争力空间分布呈明显的区域化特征,且与国家经济发展水平显著相关,地中海地区港口竞争力普遍较强,亚洲次之,非洲最弱。② 港口的网络地位对竞争力的影响最大,竞争力强的港口多位于重要水域的战略通道,网络地位高,辐射范围广。③ 我国投资的部分沿线港口综合竞争力与成熟港口之间还存在一定差距,但是具备较大的竞争力提升空间。     

The social impacts of tourism — A case study in Dali,Yunnan province,China

Ancient town Dali is located in northwest Yunnan Province. With its ancient history and natural scenery, it is preserved as one of the first 24 historical and cultural towns in China. Dali has become one of the most popular attractions for foreign tourists since it had its first foreign visitors in 1983. As a result, English came into the life of the local people. This paper presents and explains the results of questionnaires and interviews about Dali people’s attitude toward learning English. Three types of questionnaires were designed to local businessmen, local residents and foreign tourists. Interviews were also given whenever possible. In this study, businessmen in Dali were divided into two distinct groups. One group had their business in “Foreigners’ Street”, which was in front of Hongshancha Hotel where many foreign tourists stayed. Another group had business in Fuxin Street, which was vertically across “Foreigners’ Street”. The 41 shops and restaurants in “Foreigners’ Street” served mainly foreign visitors, and most of them had English names and advertisements. The 353 shops and restaurants in Fuxin Street mainly catered for domestic visitors but also served more and more overseas ones. Subjects from local residents were mostly young people because aging ones were apparently not much affected by English. The results of the study showed that the oral English levels became lower from “Foreigners’ Street” to Fuxin Street to local residents, due to declining frequency of contact with foreign people. There were also distinct differences in general English level, the understanding of the importance of English, the purposes of communicating with foreign tourists, the willingness and purposes of going on learning English between businessmen in “Foreigners’ Street” and Fuxin Street: people in “Foreigners’ Street” had more positive feedback than those in Fuxin Street because their constant contact with foreigners required them to speak better English which enabled them to exchange with foreigners in many aspects, which in turn help them to know more about other cultures. On the other hand, Fuxin Street businessmen would catch up with more and more prospective contact with overseas people. Though local residents had nothing to do with foreign tourists, they met them in the street every day and might have to talk with them in unexpected ways. They lived in a place where they saw English advertisement every day. Accordingly, study results showed that they were very much motivated to learn English. They showed even stronger desire to learn more English than businessmen in “Foreigners’ Street”, though many of them were too young to tell why English was so important for them. This is an indication that English has become part of the necessary education for young people in Dali. With the development of tourism, Dali is gradually becoming a place where Chinese culture and western culture meet and coexist. This project was supported by National Natural Science Foundation of China.     

Meridional distribution of 226Ra in the west pacific and the southern ocean surface waters

During the 13^th (1996–1997) and the 19^th (2002–2003) Chinese National Antarctica Research Expeditions, we collected 60 discrete surface seawater samples along the cruise from the Chanjiang River (Yangtze) estuary (30°59′S, 122°26′E) through Taiwan Strait, the South China Sea, and the Eastern Indian Ocean to Prydz Bay, Antarctica (69°10′S, 74°30′E), and analyzed them for the ²²⁶Ra specific activity. The ²²⁶Ra specific activity of the Chanjiang River estuary surface water (3.15 Bq/m³) was found to be the highest among all the surface samples because of the desorption of ²²⁶Ra from riverine particles. Between Chanjiang River estuary and 40°S, ²²⁶Ra specific activity was found to be relatively uniform with a mean value of 1.07 Bq/m³ (n = 19, SD = 0.14), similar to that of the open ocean. From 40°S to 65°S, ²²⁶Ra specific activity increased intensively, then decreased moderately further southwards. Near the Antarctic shore, it increased again, to 2.31 Bq/m³. This distribution was controlled by a combination of deep water upwelling, Southern Ocean fronts, water mixing and the continental ²²⁶Ra import. In Prydz Bay and the adjacent sea area, the mean ²²⁶Ra activity value was 2.26 Bq/m³ (n = 31, SD = 0.28), with a relatively higher value outside of the bay and low ²²⁶Ra activity value in the center of the bay. This was consistent with the topography and hydrological setting of the bay. In addition, we extended the study area northward to the Arctic, by combining the published ²²⁶Ra dataset for surface water from the Bering Sea to the Japan Sea. We also discuss the ²²⁶Ra distribution of high latitude oceanic surface water and its mechanisms.