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周围型小肺癌动态增强MRI与18F FDG PET/CT的相关性初探
引用本文:冯峰,夏淦林,强福林,施冬辉,沈爱军,傅爱燕,李海明,张明珠.周围型小肺癌动态增强MRI与18F FDG PET/CT的相关性初探[J].CT理论与应用研究,2017,26(4):467-472.
作者姓名:冯峰  夏淦林  强福林  施冬辉  沈爱军  傅爱燕  李海明  张明珠
作者单位:南通市肿瘤医院影像科, 江苏 南通 226361
基金项目:南通市科技局资助项目,南通市卫生局青年基金资助项目
摘    要:目的:探讨周围型小肺癌动态增强磁共振成像(DCE-MRI)定量参数和18F-2-脱氧葡萄糖正电子体层摄影/计算机体层摄影(18F FDG PET/CT)最大标准摄取值(SUVmax)的相关性。方法:27例最大径 ≤ 3 cm的周围型小肺癌行18F FDG PET/CT及动态增强MR扫描。测量磁共振定量参数容量转运常数(Ktrans)、回流速率常数(Kep)、细胞外对比剂容积分数(Ve)及PET/CT最大标准摄取值(SUVmax)。比较动态增强MRI三个定量参数值与SUVmax的相关性。结果:DCE-MRI的定量参数Ktrans值、Kep值分别与PET/CT半定量参数SUVmax之间存在正相关(P<0.05);而Ve与SUVmax无相关性(P>0.05)。结论:DCE-MRI定量参数Ktrans值及Kep值与SUVmax正相关,三者可共同反映周围型小肺癌的恶性特征。 

关 键 词:周围型肺癌    体层摄影术    X线计算机    灌注    正电子发射体层摄影术
收稿时间:2017-01-09

A Preliminary Study of Correlation between Dynamic Contrast Enhancement MRI and 18F-FDG PET/CT in Small Peripheral Lung Cancer
FENG Feng,XIA Gan-lin,QIANG Fu-lin,SHI Dong-hui,SHEN Ai-jun,FU Ai-yan,LI Hai-ming,ZHANG Ming-zhu.A Preliminary Study of Correlation between Dynamic Contrast Enhancement MRI and 18F-FDG PET/CT in Small Peripheral Lung Cancer[J].Computerized Tomography Theory and Applications,2017,26(4):467-472.
Authors:FENG Feng  XIA Gan-lin  QIANG Fu-lin  SHI Dong-hui  SHEN Ai-jun  FU Ai-yan  LI Hai-ming  ZHANG Ming-zhu
Affiliation:Department of Radiology, Nantong Tumor Hospital, Nantong 226361, China
Abstract:Objective: To investigate the correlations of the dynamic contrast enhancement MRI (DCE-MRI) and glucose metabolism determined by the maximum standardized uptake value (SUVmax) at 18F-FDG PET/CT in small peripheral cell lung cancer. Methods: 18F-FDG PET/CT and DCE-MRI wereperformed in 27 consecutive patients with histologically verifiedsmall peripherallung cancer (maximal diameter ≤ 3 cm). The quantitative MR pharmaeokineticparameters including Ktrans, Kep, Ve and SUVmax were measured. Pearson's correlations were conducted between the three MR parameters and SUVmax.Results: Positive correlations were found between Ktrans and SUVmax, Kep and SUVmax (P < 0.05). No significant correlation was found for thecomparison of Ve and SUVmax (P>0.05). Conclusions: Positive correlationswere found between Ktrans and SUVmax, Kep and SUVmax. Combination of three parameters can reflect the malignant feature of lung cancer.
Keywords:peripheral lung cancer  tomography  X-ray computed  perfusion  positron emission tomography
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