| 非刚性配准提高孤立性肺结节DCE-MRI测量可重复性的研究 |
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| 引用本文： | 张明珠,冯峰,夏淦林,陈瑜凤,傅爱燕,施冬辉.非刚性配准提高孤立性肺结节DCE-MRI测量可重复性的研究[J].CT理论与应用研究,2020,29(1):1-10. |
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| 作者姓名： | 张明珠 冯峰 夏淦林 陈瑜凤 傅爱燕 施冬辉 |
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| 作者单位： | 南通市肿瘤医院影像科, 江苏南通 226361) |
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| 基金项目： | 南通市科技局应用研究项目（MS22015107）；南通市卫计委青年基金（WQ2014047）。 |
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| 摘 要： | 目的:探讨非刚性配准前后多期动态对比增强磁共振成像(DCE-MRI)扫描定量分析孤立性肺结节的可重复性研究。方法:使用1.5T磁共振对27例孤立性肺结节患者行DCE-MRI扫描。应用Omnikinetics软件对DCE-MRI图像进行非刚性校准。两位放射科医师测量校准前后DCE-MRI定量参数:容量转移常数(k^trans)、速率常数(kep)、血管外细胞间隙容积比(ve)各两次,两次测量间隔两周。采用组内相关系数(ICC)及Bland-Altman法分析测量者内部和测量者间一致性以及可重复性。结果:同一测量者进行两次测量,配准前k^trans、kep和ve的ICC分别为0.962、0.736和0.708,配准后,ICC分别为0.983、0.962和0.834。配准后较配准前均有所提高。配准前k^trans、kep和ve测量值的可重复性分别为4.8%、33.5%和9.6%,配准后分别为1.6%、13.9%和4.3%。配准后可重复性较配准前好。不同测量者之间,配准前k^trans、kep和ve的ICC分别为0.945、0.760和0.931,配准后,ICC分别为0.988、0.962和0.976。配准后k^trans、kep和ve测量值的可重复性分别为1.8%、13.7%和13.1%较配准前的可重复性分别为3.9%,35.7%和20.1%好。结论:非刚性配准技术可以提高测量孤立性肺结节DCE-MRI定量参数结果的可重复性。
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| 关 键 词： | 孤立性肺结节 磁共振成像 非刚性配准 可重复性 |
| 收稿时间： | 2019-07-22 |
Repeatability Study on Non-rigid Registration for DCE-MRI Measurement of Solitary Pulmonary Nodule |
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| Affiliation: | Department of Radiology, Nantong Tumor Hospital, Nantong 226361, China) |
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| Abstract: | Objective:To investigate the repeatability before and after non-rigid registration in dynamic contrast-enhanced MRI quantitative analysis of solitary pulmonary nodules. Methods:Twenty-seven solitary pulmonary nodules underwent DCE-MRI examination on a 1.5 Tesla MR scanner. OmniKinetics software was applied with non-rigid registration of DCE-MRI. Two radiologists measured DCE-MRI quantitative parameters before and after the registration twice:capacity transfer constant (ktrans), rate constants (kep), extravascular extracellular space volume ratio (ve), measured twice two weeks apart. The Bland-Altman analysis and Intraclass correlation coefficient (ICC) were used to assess the reproducibility of the quantitative parameters of inter- and intra-observer agreement. Result:The same reader measured twice, the value of ICC were 0.962 (ktrans), 0.736 (kep), 0.708 (ve) before registration, and after were 0.983, 0.962, 0.834, respectively. After registration quantitative parameters were higher than before. After registration repeatability of ktrans, kep, ve measurement (1.6%, 13.9%, 4.3%) better than before (4.8%, 33.5%, 9.6%). Between different readers, the value of ICC were 0.945 (ktrans), 0.760 (kep), 0.931 (ve) before registration, and after were 0.988, 0.962, 0.976, after registration quantitative parameters were also higher than before. After registration repeatability of ktrans, kep, ve measurement (1.8%, 13.7%, 13.1%) better than before (3.9%, 35.7%, 20.1%), respectively. Conclusion:Non-rigid registration technique can improve the repeatability of the measurement of solitary pulmonary nodule DCE-MRI quantitative parameters. |
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