Investigation of environmental change indicators, and sedimentological, mineralogical and magnetic susceptibility studies on a 3101 cm high profile on the Dogai Coring salt lake shore, northern Tibet plateau, reveal six episodes of major climate change. These are (i) a general trend of cold and dry climate between 233. 3~223. 5 ka BP including two episodes of warmer climate followed by gradual climate cooling; (ii) a sharp increase in temperature between 223. 5~213. 6 ka BP; (iii) an overall colder climate between 213. 6~170 ka BP that was interrupted by two warm and wet events; (iv) between 117. 1 ka B. P. ~75. 6 ka B. P. the climate trended towards decreasing temperatures; and (vi) a hot and humid climate between 75. 6~56. 7 ka BP. Evidence of past climate variability and its periodicity has been preserved in polar ice cores and the deep sea oxygen isotope records. However, there is a contrast between the midPleistocene palaeoclimate changes recorded in the Dongai Coring salt lake and the CH0310 borehole from the Qarhan saline lake in Qaidam basin and the QH- 86 borehole on the south bank of Qinghai Lake. find that it is comparable with Qaidam basin salt lake and Qinghai lake on ancient climate change regularity.