Abstract: A large volume of granitoid plutons formed during late Carboniferous to early Permian in the South Tianshan Orogenic belt. These rocks can be generally classed as Late Carboniferous I-type granites, Early Permian I and S-type granites, and A-type granites that formed at ~275Ma. In this paper, seven granitoid plutons, including Tielieke pluton, Mangqisu pluton, Yingmailai pluton, Chuanwulu pluton, Baleigong pluton, Huoshibulake pluton and Mazhashan pluton, in the Chinese South Tianshan Orogenic belt are chosen for geochronological, petrological, and geochemical investigations. Tielieke and Mangqisu plutons are Late Carboniferous I-type granites. The magmas, representing the syn-collisional granitoid magmatism, derived from the metaigneous rocks in lower crust. The Early Permian S-type granite is represented by Yingmailai pluton, which is indicative of the remelting of Mesoproterozoic metasedimentary and metaigneous rock induced by the radiogenic heating. Felsic rocks in Chuanwulu pluton are I-type granites, representing the hybrid magmas that derived from the lower part of the thickened continental crust. The source of mafic rocks in the Chuanwulu pluton is a metasomatized lithospheric mantle. The nature of Yingmailai and Chuanwulu plutons suggests a transitionary setting between syn-collisional setting and post-collisional setting. A-type granites, which are generally have ages of ~275Ma, indicate the interaction between asthenosphere and lower crust. Baleigong pluton is A2-type, representing the epilogue of the post-collisional setting; however, Huoshibulake and Mazhashan plutons are A1-type and associated with the rift regime.