Abstract: Garnet U-Pb dating has advantages in directly constraining the ore-formation age and has been successfully applied in recent years. As the important part of the Middle and Lower Yangtze River, the Chizhou area has experienced intensive Yanshanian magmatism, simultaneously accompanied by multi-period metal mineralization. Nevertheless, due to the ore bodies reserved in the surrounding sedimentary rocks, the time of Pb and Zn mineralization in the Chizhou area is still vague. Therefore, the in-situ U-Pb dating for zircon from dykes and garnet from skarn in the Xuqiao-Wugudun Pb-Zn deposit was carried out. In the Wugudun mining area, there are two types of magmatic dykes. One is diorite porphyries which closely related to Mo and Cu mineralization with ages ranging from 146～141 Ma and the other is fine-grained granites which closely related to Mo mineralization with age of 113.4±2 Ma. The garnet U-Pb dating gives results of 148～143 Ma which are consistent with the ages of diorite porphyries. Based on available data, there were three stages of diagenesis and mineralization in Chizhou area： the first stage （150～135 Ma） mainly generated intermediate-acid intrusions and associated deposits of Cu, Au, Mo, Pb and Zn. The second stage （134～124 Ma） formed K-feldspar granite and related Pb, Zn and Mo deposits. In the third stage （115～110 Ma）, the magmatic activity was near the end, and mainly produced some the granitic dykes, accompanied by weak Mo mineralization. Combined with regional metallogenic regularity, the mineralization in Chizhou area is not completely the same as that in the Middle and Lower Yangtze River, and the multi-phase Mo （W） mineralization in the Chizhou area may be related to the multi-stage activation of the Meso-Neoproterozoic accreted crust.