| 摘要: |
| 目的：优选复方莪术散颗粒的最佳提取与颗粒制备工艺，为该复方的开发利用提供试验依据。方法：采用正交试验法对复方莪术散进行提取，以淫羊藿苷的含量和收率综合评价为指标，通过L9（34）正交试验设计对醇的用量、提取的时间和提取次数进行考察，优选复方莪术散的醇提取工艺，再以浸膏为原料，通过L9（34）正交试验设计考察稀释剂（可溶性淀粉）的比例及粘合剂（乙醇）的浓度和干燥温度，制备复方莪术散颗粒。结果：复方莪术散提取最佳工艺为A2B22C11D1，即处方药材加60%浓度的10倍剂量的乙醇，提取2次，每次1.5h为最优。最佳制备工艺为A3B2C2，即干浸膏∶淀粉的比例为1∶2.5，并以90%乙醇为湿润剂，采用湿法制粒的方法，干燥温度为60℃，所制得颗粒剂经检查符合相关要求。结论：本试验所得复方莪术散颗粒剂的提取与制备工艺合理、可行，为该复方的开发利用提供了试验依据。 |
| 关键词: 复方莪术散 提取工艺 颗粒制备 正交试验 |
| DOI： |
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| Optimization of extraction and granule preparation processes of compound Ezhu powder based on the orthogonal test |
| WANG Ping,CAO Baoli,LI Dihua |
| (Tianjin University of Traditional Chinese Medicine，Tianjin 300100，China;Tianjin Nankai Hospital，Tianjin 300100，China) |
| Abstract: |
| Objective：To investigate the optimization of extraction and granule preparation processes of compound Ezhu powder，and to provide an experimental basis for the development and utilization of this compound prescription.Methods：The orthogonal test was used for the extraction of compound Ezhu powder.With the content and yield of icariin as evaluation indices，the L9（34）orthogonal test was used to evaluate the amount of ethanol，extraction time，and times of extraction and determine the optimal ethanol extraction process of compound Ezhu powder.With the extract as raw material，the L9（34）orthogonal test was used to evaluate the proportion of the diluent（soluble starch），the concentration of the glue（ethanol），and drying temperature for the preparation of compound Ezhu granules.Results：The optimal extraction process of compound Ezhu powder was A2B2C1D1 and performed in the following steps：the prescribed medicinal material was mixed with 60% ethanol（10times），and extraction was carried out twice，with 1.5 hours for each extraction.The optimal preparation process was A3B2C2，i.e.，a dry extract/starch ratio of 1∶2.5，the wetting agent of 90% ethanol，the method of wet granulation，and a drying temperature of 60℃，and the granules obtained met related requirements.Conclusion：The extraction and preparation processes of compound Ezhu powder obtained by this experiment are reasonable and feasible and provide an experimental basis for the development and utilization of this compound prescription. |
| Key words: compound Ezhu powder extraction process granule preparation orthogonal test |
