Abstract: A case study of the Yuqiupo landslide in Kaiyang County, Guizhou Province, the particle flow discrete element (PFC^3D) was used to simulate the failure process of the landslide. The landslide model was built through the Ball-Wall method, and the characteristics of their destructive movement was described through the monitoring of the displacement and velocity of the particles at different key parts of the landslide. The results show that the rainfall is the direct inducing factor of the Yuqiupo landslide. In the initial stage of failure, the landslide is mainly creep deformation. The landslide continuously squeezes the slope toe with the increase of the deformation. The landslide rock-soil mass reaches the stress equilibrium limit, leading to shear failure at the slope foot, and the landslide happens with upward traction development, the failure mode is creep-crack, and it is traction failure according to the mechanical conditions. The maximum sliding speed of the landslide is 12.4 m/s, the maximum sliding slip is 80 m, and the sliding stage lasts for 50 s. The results have a good applicability to simulate the process of landslide destruction, which can provide a reference for engineering construction.