The authors used the Useries isochron model of total sample dissolution to determine successfully the age of clay sediments with varied contents of carbonate in the core taken from hole SZK01 in Zabuye Lake in the southwest of the northern Tibetan Plateau and established the continuous isotope timescale of lakes 4000 m above sea level in the last 120 ka in the interior of the Tibetan Plateau, thereby providing the timespace coordinates for the research on the paleoclimate and paleoenvironment in the Lake Zabuye region and its neighboring areas as well as the relationship between evolution of the Tibetan Plateau and global changes. According to the data of 230Th/U ages, the average sedimentation rate at hole SZK01 is about 68 cm/ka. However, the sedimentation rates of different intervals differ greatly, varying from 20.8 to 128.8 cm/ka. This variation reflects the implication of the environmental change of the lake from an ephemeral deep lake through an undulating lake and lakeshore to a salt lake, which is consistent with the result of the study of highresolution hole SZK02. In this paper, we discuss the adaptability of the dating model and the U sealing of samples and superiority of its application. Further work on the U and Th isotope chemical behaviors in various hydrologic regimes and examination of the effects of multiple Th sources in sediments on dating is necessary to develop the Useries technique for the study of late Quaternary lacustrine deposits and paleoclimate of arid and semiarid continental environments.