With the growth of the nuclear power industry and the reduction in high-quality sites, the third-generation AP1000 semi-active tube-ring hybrid nuclear power plant is likely to build on non-bedrock sites, facing near-site vibration. Therefore, it is crucial to research near faults comprehensively and evaluate the seismic performance and reliability of near-fault nuclear plant sites. In this study, the dual effects of the hard soil foundation and horizontal displacement limiter on the structure were first considered. According to ATC-63, 15 groups of far-field and 14 groups of near-field ground motions were selected, and the material strain was taken as the damage index. Then, the seismic damages of the AP1000 tube-ring hybrid workshop with and without a base-isolation device were compared and analyzed. Next, different effects of base-isolation measures of the building structure under near-field and far-field earthquakes were explored. Results showed that the base-isolation measures for the tube-ring hybrid workshop have an obvious isolation effect under a near-field earthquake action, which is smaller than that under far-field earthquakes. Under the near-field ground motion, the fourth-level damage safety of the workshop with the base-isolation device is greater than that without the base-isolation device. However, the fourth-level damage safety still meets code requirements. Therefore, constructing a workshop on non-bedrock sites in near-fault areas is feasible.